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EXOSC4 and SKIV2L2
Number of citations of the paper that reports this interaction (PMID
11719186
)
268
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
EXOSC4
SKIV2L2
Gene Name
exosome component 4
superkiller viralicidic activity 2-like 2 (S. cerevisiae)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Catalytic Step 2 Spliceosome
Molecular Function
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
MRNA Splicing, Via Spliceosome
Maturation Of 5.8S RRNA
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HNRNPD
LRRC8D
MPP6
MPZL1
NEK1
SKIV2L
SKIV2L2
SMPD4
TSEN15
UPF1
UPF2
UPF3B
14 interactors:
DIS3
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
MPHOSPH6
MPP6
PBX2
SP1
UPF2
XRN1
Entrez ID
54512
23517
HPRD ID
16221
13777
Ensembl ID
ENSG00000178896
ENSG00000039123
Uniprot IDs
Q9NPD3
P42285
Q3MHC9
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Aromatic Compound Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
NcRNA Metabolic Process
Cellular Macromolecule Catabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Catabolic Process
Maturation Of 5.8S RRNA
RNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis
Gene Expression
Nucleic Acid Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Localization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
RNA Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cellular Metabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
DNA Deamination
Histone MRNA Catabolic Process
Dosage Compensation By Inactivation Of X Chromosome
MRNA Export From Nucleus
Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Ribosome Biogenesis
NcRNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Aromatic Compound Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
MRNA Metabolic Process
RNA Metabolic Process
Nuclear MRNA Surveillance
Cellular Macromolecule Catabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Catabolic Process
Gene Expression
DNA Deamination
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Cellular Metabolic Process
Histone MRNA Catabolic Process
DNA Modification
Positive Regulation Of Cell Growth
Histone MRNA Metabolic Process
Positive Regulation Of Growth
Metabolic Process
Sequestering Of Nodal From Receptor Via Nodal Binding
Regulation Of Cell Growth
Negative Regulation Of Nodal Signaling Pathway
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
Tagcloud
?
accessed
actg1
affymetrix
b2m
bafl
bioinformatics
broadly
c12orf35
cbaciu
de
devastating
dynlt1
edu
filtering
handle
html
ilkap
lo
pipeline
qrt
reasonable
sals
suite
supplementary
tardbp
tm4
twelve
uncc
webpages
Tagcloud (Difference)
?
accessed
actg1
affymetrix
b2m
bafl
bioinformatics
broadly
c12orf35
cbaciu
de
devastating
dynlt1
edu
filtering
handle
html
ilkap
lo
pipeline
qrt
reasonable
sals
suite
supplementary
tardbp
tm4
twelve
uncc
webpages
Tagcloud (Intersection)
?