DNM2 and ITSN2

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		DNM2	ITSN2
Gene Name		dynamin 2	intersectin 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Microtubule Plasma Membrane Coated Pit Focal Adhesion Postsynaptic Density Growth Cone Midbody Endocytic Vesicle Membrane Postsynaptic Membrane Extracellular Vesicular Exosome	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Synaptic Vesicle Transport Neuron Projection Morphogenesis Regulation Of Nitric-oxide Synthase Activity Membrane Organization Negative Regulation Of Membrane Tubulation	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation Golgi Associated Vesicle Biogenesis L1CAM interactions Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Metabolism of nitric oxide Gap junction trafficking and regulation NOSTRIN mediated eNOS trafficking MHC class II antigen presentation eNOS activation and regulation trans-Golgi Network Vesicle Budding Innate Immune System Formation of annular gap junctions Signalling by NGF Gap junction trafficking NGF signalling via TRKA from the plasma membrane Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Adaptive Immune System
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282)	Working memory ( 21107309)
Protein-Protein Interactions		52 interactors: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1 FNBP1L GDF9 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 PDE6G PFN1 PPIB PSTPIP1 PTK2 RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 ZBTB16 ZFAND6	75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		1785	50618
HPRD ID		03852	09193
Ensembl ID		ENSG00000079805	ENSG00000198399
Uniprot IDs		P50570 Q8N1K8	A6H8W8 Q9NZM3
PDB IDs		2YS1	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Organic Substance Chemotaxis Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling Transport Neurotrophin TRK Receptor Signaling Pathway Viral Process Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Protein Complex Assembly Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cellular Component Organization Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Catalytic Activity Response To Organic Substance Nervous System Development Neuron Development Cell Projection Organization Response To External Stimulus Apoptotic Process Cellular Component Assembly Programmed Cell Death Cell Migration Immune System Process Axonogenesis Cell Death	Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Difference) ?		bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Intersection) ?