DNM2 and PALS2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		DNM2	PALS2
Description		dynamin 2	protein associated with LIN7 2, MAGUK p55 family member
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Uropod Podosome Cytoplasm Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Endomembrane System Postsynaptic Density Membrane Clathrin-coated Vesicle Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Postsynaptic Membrane Recycling Endosome Extracellular Exosome Anchoring Junction Presynapse	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Hydrolase Activity SH3 Domain Binding Enzyme Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Autophagy Centrosome Cycle Signal Transduction Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Transport Neuron Projection Morphogenesis Protein Polymerization Membrane Organization Actin Filament Bundle Organization Membrane Tubulation Vesicle Scission Negative Regulation Of Membrane Tubulation	Protein-containing Complex Assembly
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1
Drugs
Diseases		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)
Interacting Genes		74 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CEBPA CTTN DDX39B DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L FXR1 FXR2 GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PCNT PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6	31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1
Entrez ID		1785	51678
HPRD ID		03852	09509
Ensembl ID		ENSG00000079805	ENSG00000105926
Uniprot IDs		P50570 Q8N1K8	B8ZZG1 Q9NZW5
PDB IDs		2YS1
Enriched GO Terms of Interacting Partners?		Cytosol Endocytosis Cytoplasm Import Into Cell Cadherin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Vesicle-mediated Transport Identical Protein Binding Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Metabolic Process Regulation Of Endocytosis Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Synaptic Receptor Adaptor Activity Regulation Of Signaling Dendritic Spine Positive Regulation Of Organelle Organization Clathrin-coated Pit Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Proline-rich Region Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Organelle Organization Presynaptic Endocytosis Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Synapse Regulation Of Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Transport Postsynaptic Endocytic Zone Regulation Of Vesicle-mediated Transport Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glutamatergic Synapse Ionotropic Glutamate Receptor Binding	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?