DNM2 and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DNM2	HMGB1
Description		dynamin 2	high mobility group box 1
Image
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Uropod Podosome Cytoplasm Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Endomembrane System Postsynaptic Density Membrane Clathrin-coated Vesicle Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Postsynaptic Membrane Recycling Endosome Extracellular Exosome Anchoring Junction Presynapse	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cell Surface Membrane Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Hydrolase Activity SH3 Domain Binding Enzyme Binding	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Lipid Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity Receptor Ligand Activity RAGE Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Autophagy Centrosome Cycle Signal Transduction Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Transport Neuron Projection Morphogenesis Protein Polymerization Membrane Organization Actin Filament Bundle Organization Membrane Tubulation Vesicle Scission Negative Regulation Of Membrane Tubulation	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Activation Of Innate Immune Response Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Myeloid Progenitor Cell Differentiation Immune System Process Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell Glycogen Catabolic Process DNA Metabolic Process DNA Topological Change DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Autophagy Chemotaxis Inflammatory Response Immune Response DNA Damage Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Myeloid Cell Differentiation Lung Development Neuron Projection Development Heterochromatin Formation Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Viral Entry Into Host Cell Cell Development Regulation Of Viral Process Positive Chemotaxis Regulation Of DNA Metabolic Process Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Hemopoiesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1	ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Chloroquine Ethyl pyruvate
Diseases		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		74 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CEBPA CTTN DDX39B DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L FXR1 FXR2 GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PCNT PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6	132 interacting genes: ACBD3 AGER AGTRAP AKIP1 AR ATF7IP ATOH1 C1QA C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPA CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DAG1 DLAT DNAAF2 DNM2 DNMT1 DUX4 DYNC2I1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDAC1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MALAT1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 STUB1 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM2 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 USP12 WNK4 YY1 ZFP36 ZNF24 ZNF428
Entrez ID		1785	3146
HPRD ID		03852	01228
Ensembl ID		ENSG00000079805	ENSG00000189403
Uniprot IDs		P50570 Q8N1K8	B7Z965 P09429 Q5T7C4
PDB IDs		2YS1	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO 8I9M
Enriched GO Terms of Interacting Partners?		Cytosol Endocytosis Cytoplasm Import Into Cell Cadherin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Vesicle-mediated Transport Identical Protein Binding Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Metabolic Process Regulation Of Endocytosis Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Synaptic Receptor Adaptor Activity Regulation Of Signaling Dendritic Spine Positive Regulation Of Organelle Organization Clathrin-coated Pit Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Proline-rich Region Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Organelle Organization Presynaptic Endocytosis Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Synapse Regulation Of Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Transport Postsynaptic Endocytic Zone Regulation Of Vesicle-mediated Transport Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glutamatergic Synapse Ionotropic Glutamate Receptor Binding	Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regionalization Anterior/posterior Pattern Specification Transcription Cis-regulatory Region Binding Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Pattern Specification Process Positive Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis
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