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DNM2 and AP2A1
Number of citations of the paper that reports this interaction (PMID
16696976
)
3
Data Source:
HPRD
(in vitro)
DNM2
AP2A1
Gene Name
dynamin 2
adaptor-related protein complex 2, alpha 1 subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Coated Pit
Focal Adhesion
Postsynaptic Density
Growth Cone
Midbody
Endocytic Vesicle Membrane
Postsynaptic Membrane
Extracellular Vesicular Exosome
Cytosol
Plasma Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
AP-2 Adaptor Complex
Clathrin Coat Of Trans-Golgi Network Vesicle
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Microtubule Binding
SH3 Domain Binding
Enzyme Binding
Protein Binding
Protein C-terminus Binding
Protein Transporter Activity
Protein Kinase Binding
Clathrin Adaptor Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription, DNA-templated
Post-Golgi Vesicle-mediated Transport
Endocytosis
Receptor-mediated Endocytosis
Signal Transduction
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Regulation Of Axon Extension
Receptor Internalization
Transferrin Transport
Positive Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Nitric Oxide Metabolic Process
Synaptic Vesicle Transport
Neuron Projection Morphogenesis
Regulation Of Nitric-oxide Synthase Activity
Membrane Organization
Negative Regulation Of Membrane Tubulation
Intracellular Protein Transport
Golgi To Endosome Transport
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Transmission
Axon Guidance
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Clathrin-mediated Endocytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways
Retrograde neurotrophin signalling
Axon guidance
Gap junction degradation
Golgi Associated Vesicle Biogenesis
L1CAM interactions
Recycling pathway of L1
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
Metabolism of nitric oxide
Gap junction trafficking and regulation
NOSTRIN mediated eNOS trafficking
MHC class II antigen presentation
eNOS activation and regulation
trans-Golgi Network Vesicle Budding
Innate Immune System
Formation of annular gap junctions
Signalling by NGF
Gap junction trafficking
NGF signalling via TRKA from the plasma membrane
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Adaptive Immune System
Trafficking of GluR2-containing AMPA receptors
Retrograde neurotrophin signalling
Axon guidance
HIV Infection
Nef Mediated CD8 Down-regulation
L1CAM interactions
Signaling by Wnt
Signaling by EGFRvIII in Cancer
Recycling pathway of L1
EPH-ephrin mediated repulsion of cells
MHC class II antigen presentation
EPH-Ephrin signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nef Mediated CD4 Down-regulation
EGFR downregulation
Signalling by NGF
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Host Interactions of HIV factors
Signaling by Ligand-Responsive EGFR Variants in Cancer
The role of Nef in HIV-1 replication and disease pathogenesis
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Trafficking of AMPA receptors
beta-catenin independent WNT signaling
Signaling by EGFR
WNT5A-dependent internalization of FZD4
Signaling by EGFR in Cancer
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
PCP/CE pathway
Adaptive Immune System
Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Coronary heart disease (
21347282
)
Protein-Protein Interactions
52 interactors:
AMPH
AOC1
AP2A1
APP
ATF7IP
ATXN3
BIN1
CCDC90B
CCR5
CCT7
CDK1
CTTN
DDX39B
DNM1
DYNC1I1
DYNLL1
EIF3L
EPS15
FNBP1
FNBP1L
GDF9
GRB2
HCK
HMGB1
ITSN1
ITSN2
KDR
MAN1B1
MANEA
MPHOSPH6
MPP6
PDE6G
PFN1
PPIB
PSTPIP1
PTK2
RPS2
RWDD2B
SH3GL2
SH3GLB1
SHANK1
SHANK2
SNX9
SPRY2
SRC
TIAM2
TRIP10
TYK2
VAV1
WBP4
ZBTB16
ZFAND6
27 interactors:
AMPH
AP2S1
BIN1
CLINT1
DEK
DNM2
DPYSL2
EHD1
EPN1
EPS15
GHR
HIP1
MYO6
NAGPA
NUMB
PICALM
PIN1
RAB11FIP2
RIT1
SHBG
SHC1
SMAD9
SNAP29
SYNJ1
SYT3
SYT7
TOE1
Entrez ID
1785
160
HPRD ID
03852
03016
Ensembl ID
ENSG00000079805
ENSG00000196961
Uniprot IDs
P50570
Q8N1K8
O95782
PDB IDs
2YS1
Enriched GO Terms of Interacting Partners
?
Endocytosis
Vesicle-mediated Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of ERBB Signaling Pathway
Movement Of Cell Or Subcellular Component
Locomotion
Cellular Response To Organic Substance
Chemotaxis
Cellular Localization
Regulation Of Signal Transduction
Regulation Of Signaling
Transport
Neurotrophin TRK Receptor Signaling Pathway
Viral Process
Positive Regulation Of Cellular Component Biogenesis
Peptidyl-tyrosine Autophosphorylation
Neurotrophin Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Protein Complex Assembly
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Establishment Of Localization In Cell
Regulation Of Cell Death
Negative Regulation Of ERBB Signaling Pathway
Neuron Projection Morphogenesis
Positive Regulation Of Protein Complex Assembly
Neuron Projection Development
Axon Guidance
Cell Projection Morphogenesis
Cell Part Morphogenesis
Regulation Of Cellular Component Organization
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Catalytic Activity
Response To Organic Substance
Nervous System Development
Neuron Development
Cell Projection Organization
Response To External Stimulus
Apoptotic Process
Cellular Component Assembly
Programmed Cell Death
Cell Migration
Immune System Process
Axonogenesis
Cell Death
Vesicle-mediated Transport
Endocytosis
Clathrin Coat Assembly
Establishment Of Localization In Cell
Synaptic Vesicle Transport
Cellular Localization
Regulation Of Vesicle-mediated Transport
Membrane Budding
Transport
Cellular Protein Complex Assembly
Establishment Of Vesicle Localization
Vesicle Organization
Vesicle Localization
Synaptic Transmission
Signaling
Membrane Organization
Cell Communication
Cellular Macromolecular Complex Assembly
Cell-cell Signaling
Establishment Of Organelle Localization
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Regulation Of Endocytosis
Regulation Of ERBB Signaling Pathway
Regulation Of Cellular Component Organization
Organelle Localization
Neuron Development
Synaptic Vesicle Endocytosis
Synaptic Vesicle Recycling
Protein Complex Assembly
Positive Regulation Of Transport
Secretion By Cell
Cellular Component Assembly
Receptor Internalization
Neuron Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cell Projection Organization
Negative Regulation Of ERBB Signaling Pathway
Generation Of Neurons
Exocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Vesicle Priming
ERBB Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Neurogenesis
Secretion
Neuron Projection Morphogenesis
Response To Stimulus
Cellular Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud
?
bcl11b
cadherin
discovered
druggable
exhibitedthe
fat1
fbxw7
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Difference)
?
bcl11b
cadherin
discovered
druggable
exhibitedthe
fat1
fbxw7
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Intersection)
?