DNM2 and SNX9

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		DNM2	SNX9
Description		dynamin 2	sorting nexin 9
Image
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Uropod Podosome Cytoplasm Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Endomembrane System Postsynaptic Density Membrane Clathrin-coated Vesicle Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Postsynaptic Membrane Recycling Endosome Extracellular Exosome Anchoring Junction Presynapse	Ruffle Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cuticular Plate Cell Projection Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Hydrolase Activity SH3 Domain Binding Enzyme Binding	Protein Binding 1-phosphatidylinositol Binding Lipid Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Autophagy Centrosome Cycle Signal Transduction Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Transport Neuron Projection Morphogenesis Protein Polymerization Membrane Organization Actin Filament Bundle Organization Membrane Tubulation Vesicle Scission Negative Regulation Of Membrane Tubulation	Mitotic Cell Cycle Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Division Lipid Tube Assembly Protein-containing Complex Assembly Plasma Membrane Tubulation Regulation Of Synaptic Vesicle Endocytosis
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)	Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494)
Interacting Genes		74 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CEBPA CTTN DDX39B DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L FXR1 FXR2 GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PCNT PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6	25 interacting genes: ADAM15 ADAM9 AP1G1 CEBPA CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MECOM MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL
Entrez ID		1785	51429
HPRD ID		03852	12072
Ensembl ID		ENSG00000079805	ENSG00000130340
Uniprot IDs		P50570 Q8N1K8	Q9Y5X1
PDB IDs		2YS1	2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE 7OJ9
Enriched GO Terms of Interacting Partners?		Cytosol Endocytosis Cytoplasm Import Into Cell Cadherin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Vesicle-mediated Transport Identical Protein Binding Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Metabolic Process Regulation Of Endocytosis Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Synaptic Receptor Adaptor Activity Regulation Of Signaling Dendritic Spine Positive Regulation Of Organelle Organization Clathrin-coated Pit Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Proline-rich Region Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Organelle Organization Presynaptic Endocytosis Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Synapse Regulation Of Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Transport Postsynaptic Endocytic Zone Regulation Of Vesicle-mediated Transport Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glutamatergic Synapse Ionotropic Glutamate Receptor Binding	SH3 Domain Binding Plasma Membrane Clathrin-coated Pit Vesicle Budding From Membrane Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Endocytosis Immune System Process Clathrin-coated Vesicle Phosphatidylinositol 3-kinase Complex, Class IB Import Into Cell Intracellular Signaling Cassette Kinase Activity Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Focal Adhesion Regulation Of Hematopoietic Progenitor Cell Differentiation Cytosol Regulation Of Immune System Process Phosphatidylinositol 3-kinase Complex Regulation Of Pro-B Cell Differentiation Regulation Of Cellular Component Organization Extracellular Exosome Phosphatidylinositol 3-kinase Complex, Class IA Cytoplasm Actin Filament-based Movement Epidermal Growth Factor Receptor Signaling Pathway Transferrin Transport Receptor-mediated Endocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphoid Progenitor Cell Differentiation Protein Serine Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Receptor Internalization Cellular Response To Type II Interferon Vesicle-mediated Transport Regulation Of ERBB Signaling Pathway Regulation Of Protein Metabolic Process Protein Polymerization Eyelid Development In Camera-type Eye ERBB Signaling Pathway Insulin Receptor Signaling Pathway Apoptotic Process Regulation Of Macromolecule Metabolic Process
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