DNM2 and FNBP1L

Number of citations of the paper that reports this interaction (PubMedID 16418535)
41

Data Source:
BioGRID (pull down)

		DNM2	FNBP1L
Description		dynamin 2	formin binding protein 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Uropod Podosome Cytoplasm Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Endomembrane System Postsynaptic Density Membrane Clathrin-coated Vesicle Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Postsynaptic Membrane Recycling Endosome Extracellular Exosome Anchoring Junction Presynapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Hydrolase Activity SH3 Domain Binding Enzyme Binding	Protein Binding Lipid Binding Cadherin Binding GTPase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Autophagy Centrosome Cycle Signal Transduction Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Transport Neuron Projection Morphogenesis Protein Polymerization Membrane Organization Actin Filament Bundle Organization Membrane Tubulation Vesicle Scission Negative Regulation Of Membrane Tubulation	Endocytosis Vesicle Budding From Membrane Autophagy Signal Transduction Membrane Invagination Vesicle Organization Vesicle Transport Along Actin Filament Positive Regulation Of Filopodium Assembly Cilium Assembly Clathrin-dependent Endocytosis Plasma Membrane Tubulation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1	Clathrin-mediated endocytosis CDC42 GTPase cycle RHOJ GTPase cycle
Drugs
Diseases		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)	Alanine aminotransferase levels ( 33547301) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Triglyceride levels ( 29403010 33339817)
Interacting Genes		74 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CEBPA CTTN DDX39B DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L FXR1 FXR2 GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PCNT PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6	6 interacting genes: ACP1 CDC42 DNM2 SGSM2 USP13 WASL
Entrez ID		1785	54874
HPRD ID		03852	12317
Ensembl ID		ENSG00000079805	ENSG00000137942
Uniprot IDs		P50570 Q8N1K8	B4DSI7 Q5T0N5
PDB IDs		2YS1
Enriched GO Terms of Interacting Partners?		Cytosol Endocytosis Cytoplasm Import Into Cell Cadherin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Vesicle-mediated Transport Identical Protein Binding Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Metabolic Process Regulation Of Endocytosis Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Synaptic Receptor Adaptor Activity Regulation Of Signaling Dendritic Spine Positive Regulation Of Organelle Organization Clathrin-coated Pit Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Proline-rich Region Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Organelle Organization Presynaptic Endocytosis Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Synapse Regulation Of Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Transport Postsynaptic Endocytic Zone Regulation Of Vesicle-mediated Transport Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glutamatergic Synapse Ionotropic Glutamate Receptor Binding	Negative Regulation Of Membrane Tubulation Dendritic Spine Morphogenesis Regulation Of Plasma Membrane Organization Cell Projection Morphogenesis Actin Filament Organization Positive Regulation Of Filopodium Assembly Establishment Of Organelle Localization Neuron Projection Morphogenesis Dendritic Spine Organization Vesicle Budding From Membrane Neuron Projection Organization Postsynapse Organization Regulation Of Filopodium Assembly Actin Cytoskeleton Organization Actin Filament-based Process Endocytic Vesicle Membrane Protein Polymerization Organelle Localization Supramolecular Fiber Organization Establishment Of Vesicle Localization SH3 Domain Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly GBD Domain Binding Storage Vacuole Vesicle Scission Vesicle Localization Establishment Of Localization In Cell Hydrolase Activity Membrane Organization Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Protein K6-linked Deubiquitination Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Cellular Component Organization Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Actin Cap Midbody Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Cytoskeleton-dependent Intracellular Transport Acid Phosphatase Activity Membrane Tubulation Vesicle Transport Along Actin Filament Late Endosome To Golgi Transport Cytoplasmic Vesicle Positive Regulation Of Pinocytosis
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