DHX9 and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 11687588)
0

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)

		DHX9	ACTA1
Description		DExH-box helicase 9	actin alpha 1, skeletal muscle
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding Ribosome Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding RNA Polymerase Binding Catalytic Activity, Acting On A Nucleic Acid RISC Complex Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Osteoblast Differentiation Immune System Process DNA Replication Chromatin Organization DNA-templated Transcription Termination Regulation Of Transcription By RNA Polymerase II MRNA Processing Regulation Of Translation Inflammatory Response RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing DNA-templated Viral Transcription Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Protein-containing Complex Assembly Pyroptotic Inflammatory Response RISC Complex Assembly CRD-mediated MRNA Stabilization Cellular Response To Exogenous DsRNA Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway PKR-mediated signaling	Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS
Interacting Genes		44 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DUX4 GEMIN2 GEMIN4 GTF2B HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 LINC01016 LINC01554 MBD2 NXF1 OGA OGT PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA RNF10 RNF168 SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I USP7 YWHAQ	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		1660	58
HPRD ID		04386	00030
Ensembl ID		ENSG00000135829	ENSG00000143632
Uniprot IDs		B3KU66 Q08211	P68133
PDB IDs		3LLM 3VYX 3VYY 8SZP	7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		RNA Splicing Nucleoplasm MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process Nucleus RNA Binding SMN-Sm Protein Complex Nucleobase-containing Compound Metabolic Process Spliceosomal SnRNP Assembly Macromolecule Metabolic Process RNA Processing SMN Complex Gemini Of Cajal Bodies RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Protein-RNA Complex Assembly Spliceosomal Complex Assembly Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Nuclear Body Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process MRNA Binding Protein-containing Complex Assembly Ribonucleoprotein Complex Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
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