DHX9 and HDLBP

Number of citations of the paper that reports this interaction (PMID 15723802)
27

Data Source:
HPRD (in vitro)

		DHX9	HDLBP
Gene Name		DEAH (Asp-Glu-Ala-His) box helicase 9	high density lipoprotein binding protein
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex	Nucleus Cytoplasm Plasma Membrane High-density Lipoprotein Particle
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding RNA Helicase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Protein Binding Lipid Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing Circadian Rhythm RNA Splicing Gene Expression Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Cellular Response To Heat Innate Immune Response CRD-mediated MRNA Stabilization	Lipid Transport Cholesterol Metabolic Process
Pathways		mRNA Splicing Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Processing of Capped Intron-Containing Pre-mRNA TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA mRNA Splicing - Major Pathway MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		40 interactors: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 EIF2AK2 EWSR1 GEMIN2 GEMIN4 GTF2B H2AFX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 MBD2 MGEA5 NXF1 PCNA POLR2A PRMT1 PRPF40A PRPF8 RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ	7 interactors: ADAR CSNK2A1 DHX9 FAM46A SMAD4 SOS1 XPOT
Entrez ID		1660	3069
HPRD ID		04386	00813
Ensembl ID		ENSG00000135829	ENSG00000115677
Uniprot IDs		B3KU66 Q08211	Q00341
PDB IDs		3LLM 3VYX 3VYY	1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Viral Process Positive Regulation Of DNA Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Viral Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecular Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Genome Replication	Axon Guidance Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Protein Catabolic Process Chemotaxis Nuclear Export Regulation Of Cell Death Negative Regulation Of RNA Interference TRNA Export From Nucleus Nephrogenic Mesenchyme Morphogenesis Neuron Projection Morphogenesis Osteoblast Differentiation Adenosine To Inosine Editing Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Differentiation Response To External Stimulus Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis CRD-mediated MRNA Stabilization Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process Endocardial Cell Differentiation Hematopoietic Stem Cell Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Base Conversion Or Substitution Editing Neuron Development Negative Regulation Of Cell Death Negative Regulation Of Type I Interferon-mediated Signaling Pathway Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Nucleocytoplasmic Transport Nuclear Transport Cell Morphogenesis MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Regulation Of Transforming Growth Factor Beta2 Production Ossification Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Neuron Differentiation Rhythmic Process Cell Projection Organization Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tagcloud ?			accurately adam12 cancers candidate centb1 centg1 dip2c exome gli1 grin2d hedgehog ikbkb infrequent involvement kb kpna5 mutation nfkb1 notch notch1 otof pik3ca point prevalence recurring sequencing somatic strengthen substantial
Tagcloud (Difference) ?			accurately adam12 cancers candidate centb1 centg1 dip2c exome gli1 grin2d hedgehog ikbkb infrequent involvement kb kpna5 mutation nfkb1 notch notch1 otof pik3ca point prevalence recurring sequencing somatic strengthen substantial
Tagcloud (Intersection) ?