DHX9 and LINC01016

Number of citations of the paper that reports this interaction (PubMedID 37550275)
32

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		DHX9	LINC01016
Description		DExH-box helicase 9	long intergenic non-protein coding RNA 1016
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding Ribosome Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding RNA Polymerase Binding Catalytic Activity, Acting On A Nucleic Acid RISC Complex Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Osteoblast Differentiation Immune System Process DNA Replication Chromatin Organization DNA-templated Transcription Termination Regulation Of Transcription By RNA Polymerase II MRNA Processing Regulation Of Translation Inflammatory Response RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing DNA-templated Viral Transcription Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Protein-containing Complex Assembly Pyroptotic Inflammatory Response RISC Complex Assembly CRD-mediated MRNA Stabilization Cellular Response To Exogenous DsRNA Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway PKR-mediated signaling
Drugs
Diseases
GWAS			Alanine transaminase levels ( 29403010) Multisite chronic pain ( 33830993)
Interacting Genes		44 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DUX4 GEMIN2 GEMIN4 GTF2B HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 LINC01016 LINC01554 MBD2 NXF1 OGA OGT PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA RNF10 RNF168 SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I USP7 YWHAQ	2 interacting genes: DHX9 EPRS1
Entrez ID		1660	100507584
HPRD ID		04386
Ensembl ID		ENSG00000135829	ENSG00000249346
Uniprot IDs		B3KU66 Q08211
PDB IDs		3LLM 3VYX 3VYY 8SZP
Enriched GO Terms of Interacting Partners?		RNA Splicing Nucleoplasm MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process Nucleus RNA Binding SMN-Sm Protein Complex Nucleobase-containing Compound Metabolic Process Spliceosomal SnRNP Assembly Macromolecule Metabolic Process RNA Processing SMN Complex Gemini Of Cajal Bodies RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Protein-RNA Complex Assembly Spliceosomal Complex Assembly Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Nuclear Body Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process MRNA Binding Protein-containing Complex Assembly Ribonucleoprotein Complex Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process	RNA Stem-loop Binding 3'-5' DNA/RNA Helicase Activity DNA-templated Viral Transcription Regulatory Region RNA Binding Proline-tRNA Ligase Activity Prolyl-tRNA Aminoacylation Triplex DNA Binding Glutamyl-tRNA Aminoacylation Glutamate-tRNA Ligase Activity Positive Regulation Of RNA Export From Nucleus Perichromatin Fibrils RISC Complex Binding Positive Regulation Of Viral Transcription Single-stranded 3'-5' DNA Helicase Activity Regulation Of Translation Viral Transcription Ribonucleoprotein Complex CRD-mediated MRNA Stability Complex Catalytic Activity, Acting On A Nucleic Acid GAIT Complex RISC-loading Complex Nucleoside Triphosphate Diphosphatase Activity Nuclear Stress Granule Protein Localization To Cytoplasmic Stress Granule 3'-5' RNA Helicase Activity Regulation Of Long-chain Fatty Acid Import Into Cell Importin-alpha Family Protein Binding Post-transcriptional Regulation Of Gene Expression SiRNA Binding RISC Complex Assembly Positive Regulation Of Interleukin-18 Production CRD-mediated MRNA Stabilization Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay 3'-5' DNA Helicase Activity Ribonucleoside Triphosphate Phosphatase Activity Regulation Of Interleukin-18 Production Sequence-specific MRNA Binding Cellular Response To Exogenous DsRNA DNA Replication Origin Binding Positive Regulation Of Cytoplasmic Translation Regulation Of RNA Export From Nucleus RNA Polymerase Binding DNA-templated Transcription Termination Regulation Of Viral Transcription Cellular Response To DsRNA Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Interferon-alpha Production RNA Polymerase II Complex Binding
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