MCM7 and CRLS1

Number of citations of the paper that reports this interaction (PubMedID 12771218)
35

Data Source:
HPRD (in vivo)

		MCM7	CRLS1
Description		minichromosome maintenance complex component 7	cardiolipin synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Membrane MCM Complex CMG Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Cardiolipin Synthase (CMP-forming) 2-acylglycerol-3-phosphate O-acyltransferase Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Damage Response Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of DNA-templated DNA Replication Initiation Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Lipid Metabolic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Glycerophospholipid Biosynthetic Process
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Acyl chain remodelling of PG Synthesis of CL
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		79 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEBPA CEP68 CHEK1 COG6 CRLS1 CRYAA DBF4 DNAAF6 DUX4 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 LRR1 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RNF181 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM63 UBE3A UBQLN1 USHBP1	5 interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1
Entrez ID		4176	54675
HPRD ID		01154	12187
Ensembl ID		ENSG00000166508	ENSG00000088766
Uniprot IDs		A0A0S2Z4A5 C6EMX8 C9J8M6 P33993	Q9UJA2
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Replication Origin Recognition Complex Double-strand Break Repair Via Break-induced Replication Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle Process DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Cellular Response To Stress Recombinational Repair Mitotic DNA Integrity Checkpoint Signaling Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle G1/S Phase Transition DNA Recombination Single-stranded DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Transcription Factor TFIIK Complex Mitotic G2/M Transition Checkpoint CAK-ERCC2 Complex Mitotic DNA Replication Initiation Regulation Of Lipid Kinase Activity Macromolecule Metabolic Process	CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Negative Regulation Of JNK Cascade DNA Helicase Activity Proteinase-activated Receptor Activity Regulation Of JNK Cascade Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protease Binding Positive Regulation Of Renin Secretion Into Blood Stream Helicase Activity Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Recombinational Repair Regulation Of DNA Replication DNA Replication Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Negative Regulation Of MAPK Cascade Chromosome, Telomeric Region Positive Regulation Of Killing Of Cells Of Another Organism Response To Hydrogen Sulfide Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Maintenance Of Protein Location In Mitochondrion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neutrophil Mediated Cytotoxicity Double-strand Break Repair Nuclear DNA Replication
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