MCM7 and NAB2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MCM7	NAB2
Gene Name		minichromosome maintenance complex component 7	NGFI-A binding protein 2 (EGR1 binding protein 2)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Cytosol Membrane MCM Complex	Nucleus
	Molecular Function	DNA Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding	Transcription Corepressor Activity Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus	Endochondral Ossification Transcription, DNA-templated Nervous System Development Cell Proliferation Schwann Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase III Promoter Myelination Regulation Of Epidermis Development
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS			IgE levels ( 22075330)
Protein-Protein Interactions		59 interactors: AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC45 CDC6 CDC7 CDK7 CDKN1B CDT1 CRLS1 DBF4 FHL2 GOLGA2 HIF1A HIST3H3 IKBKG INTS6 KIFC3 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RPA1 SMC1A SNTA1 SP2 TCEB1 TREX1 TRIM27 TRIM54 UBE3A UBQLN1 USHBP1	33 interactors: AES CCDC33 CCHCR1 CWF19L2 DGCR6 EGR1 EGR2 GCC1 JAKMIP2 KRT40 KRTAP10-3 KRTAP10-8 LENG1 MAPK3 MCM7 MDFI MORF4L1 NEDD9 NME7 NOTCH2NL PHF1 PHOSPHO2 PIN1 RBPMS RFC5 SCNM1 SUMO1P1 TCEANC TCHP TGIF2LY TTC19 ZBED8 ZMYND19
Entrez ID		4176	4665
HPRD ID		01154	03854
Ensembl ID		ENSG00000166508	ENSG00000166886
Uniprot IDs		C6EMX8 P33993	Q15742
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Cell Cycle Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Chromosome Organization Regulation Of Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication Checkpoint Positive Regulation Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Intracellular Receptor Signaling Pathway Metabolic Process	Response To Interleukin-1 Negative Regulation Of Binding Interleukin-1-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Cellular Response To Gonadotropin Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Epidermal Growth Factor RNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Protein Export From Nucleus DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Stress RNA Metabolic Process Response To Gonadotropin Negative Regulation Of Wnt Signaling Pathway Rhombomere 5 Formation Rhombomere 3 Formation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Apolipoprotein Binding Cellular Response To CAMP Nitrogen Compound Metabolic Process Negative Regulation Of Protein Binding Gene Expression Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Interleukin-1 Regulation Of Neuronal Synaptic Plasticity Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Modification Process Cell Cycle Rhombomere 3 Morphogenesis Regulation Of Binding Cellular Response To Mechanical Stimulus Positive Regulation Of Histone Modification BMP Signaling Pathway Brain Segmentation Response To Insulin Regulation Of Growth Regulation Of Wnt Signaling Pathway Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Anoikis Cellular Response To Mycophenolic Acid Regulation Of Golgi Inheritance
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	atypia dedifferentiated dedifferentiation dfsr dfsrs exclusive exon fibrous formalin fusions harbored hot label mitosis mutually ngfi paraffin pdgfrb pleomorphism sft solitary spot stat6 tert thoracic tp53 transcriptase transducer variations
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	atypia dedifferentiated dedifferentiation dfsr dfsrs exclusive exon fibrous formalin fusions harbored hot label mitosis mutually ngfi paraffin pdgfrb pleomorphism sft solitary spot stat6 tert thoracic tp53 transcriptase transducer variations
Tagcloud (Intersection) ?