MCM7 and CDK7

Number of citations of the paper that reports this interaction (PubMedID 11056214)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MCM7	CDK7
Description		minichromosome maintenance complex component 7	cyclin dependent kinase 7
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Membrane MCM Complex CMG Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Fibrillar Center Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm CAK-ERCC2 Complex Transcription Factor TFIIK Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Damage Response Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of DNA-templated DNA Replication Initiation Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	RNA Polymerase II Promoter Clearance DNA Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II DNA Damage Response Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Cell Division Regulation Of Cell Cycle Transcription Pausing By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs			Phosphonothreonine Alvocidib SNS-032 Seliciclib Trilaciclib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		79 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEBPA CEP68 CHEK1 COG6 CRLS1 CRYAA DBF4 DNAAF6 DUX4 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 LRR1 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RNF181 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM63 UBE3A UBQLN1 USHBP1	44 interacting genes: APP AR BRCA1 CCND2 CCNH CDK1 CDK2 CDK6 CEBPA CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 H1-1 HLA-DQA1 HSD17B4 HSPA5 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR
Entrez ID		4176	1022
HPRD ID		01154	15993
Ensembl ID		ENSG00000166508	ENSG00000134058
Uniprot IDs		A0A0S2Z4A5 C6EMX8 C9J8M6 P33993	A0A0S2Z3F9 D6R9G1 D6RFL0 P50613
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	1UA2 6O9L 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P4Z 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8P7L 8PLZ 8PYR 8R99 8R9A 8R9B 8R9O 8R9S 8R9U 8S0R 8S0T
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Replication Origin Recognition Complex Double-strand Break Repair Via Break-induced Replication Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle Process DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Cellular Response To Stress Recombinational Repair Mitotic DNA Integrity Checkpoint Signaling Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle G1/S Phase Transition DNA Recombination Single-stranded DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Transcription Factor TFIIK Complex Mitotic G2/M Transition Checkpoint CAK-ERCC2 Complex Mitotic DNA Replication Initiation Regulation Of Lipid Kinase Activity Macromolecule Metabolic Process	DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Transcription Factor TFIIH Core Complex RNA Metabolic Process Transcription Factor TFIIH Holo Complex Nucleoplasm Nucleic Acid Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcription Factor TFIID Complex Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Initiation Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleotide-excision Repair Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Regulation Of Cell Cycle DNA Repair DNA-templated Transcription Elongation DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Chromatin CAK-ERCC2 Complex Hormone-mediated Signaling Pathway Regulation Of MiRNA Metabolic Process Cellular Response To Stress Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?