MCM7 and RAD17

Number of citations of the paper that reports this interaction (PMID 15538388)
35

Data Source:
HPRD (two hybrid, in vivo)

		MCM7	RAD17
Gene Name		minichromosome maintenance complex component 7	RAD17 homolog (S. pombe)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Cytosol Membrane MCM Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm
	Molecular Function	DNA Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding	Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Regulation Of Phosphorylation
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		59 interactors: AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC45 CDC6 CDC7 CDK7 CDKN1B CDT1 CRLS1 DBF4 FHL2 GOLGA2 HIF1A HIST3H3 IKBKG INTS6 KIFC3 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RPA1 SMC1A SNTA1 SP2 TCEB1 TREX1 TRIM27 TRIM54 UBE3A UBQLN1 USHBP1	16 interactors: ATM ATR HUS1 MCM7 NHP2L1 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 USP20
Entrez ID		4176	5884
HPRD ID		01154	09124
Ensembl ID		ENSG00000166508	ENSG00000152942
Uniprot IDs		C6EMX8 P33993	O75943
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Cell Cycle Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Chromosome Organization Regulation Of Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication Checkpoint Positive Regulation Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Intracellular Receptor Signaling Pathway Metabolic Process	Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication DNA Metabolic Process Cell Cycle Process Cellular Response To Stress DNA Recombination Telomere Maintenance Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Checkpoint DNA-dependent DNA Replication Response To Stress Response To Ionizing Radiation Nucleobase-containing Compound Metabolic Process Cellular Response To Ionizing Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleotide-excision Repair Chromosome Organization Nitrogen Compound Metabolic Process Cellular Response To Radiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Biosynthetic Process Cellular Response To Stimulus Cellular Metabolic Process Double-strand Break Repair Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Organelle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Mitotic Cell Cycle Homeostatic Process
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass
Tagcloud (Intersection) ?