CHUK and H3C14

Number of citations of the paper that reports this interaction (PubMedID 17643371)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CHUK	H3C14
Description		component of inhibitor of nuclear factor kappa B kinase complex	H3 clustered histone 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Chromatin Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Contraction Regulation Of Transcription By RNA Polymerase II Inflammatory Response Immune Response Canonical NF-kappaB Signal Transduction Response To Xenobiotic Stimulus Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Response To Acetate Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interferon-alpha Production Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Cholecystokinin Cellular Response To Tumor Necrosis Factor Cellular Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Gene Expression
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs		Aminosalicylic acid Mesalazine Acetylcysteine
Diseases		Cocoon syndrome
GWAS		Liver enzyme levels ( 18940312) Psoriasis ( 28537254) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Type 2 diabetes ( 30054458)
Interacting Genes		85 interacting genes: AKT1 AKT2 AMBRA1 ATM ATR BCL10 BCL3 BTRC CASP8 CDC37 CHEK1 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 DCUN1D5 E2F4 EIF2AK2 ELP1 ERBIN ESR1 FKBP5 FOXO3 H3-4 H3C1 H3C14 HECTD3 HSP90AA1 HSP90AB1 HTT IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 MYC NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SAMHD1 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP TTC3 UBC UBE2E3 UBE2I UBE2N	66 interacting genes: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CBX2 CBX4 CBX6 CBX7 CBX8 CDCA8 CDK8 CHUK DDB2 DNAJC9 DNMT3L EHMT2 ELP3 EP300 HDGFL2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 NAP1L4 NASP NCOA6 NRDC NSD2 PHF21A PIM1 PKN1 PRMT6 PTMA PWWP3A RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1
Entrez ID		1147	126961
HPRD ID		02811	11822
Ensembl ID		ENSG00000213341	ENSG00000203811
Uniprot IDs		O15111	Q71DI3
PDB IDs		3BRT 5EBZ 5TQW 5TQX 5TQY	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA 7JZV 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7TAN 7U50 7U51 7U52 7U53 7UV9 7UVA 7XCR 7XCT 7XD0 7YRD 8AAG 8ATF 8AV6 8GRQ 8HQY 8HR1 8JLB 8JLD 8OL1 8VMJ 8VMN 8VO0 8VOB 8VWS 8VWT 8VWU 8VWV 8X7I 8X7J 8X7K 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9GMK 9GMR 9IPU
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytosol Nucleoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Apoptotic Process Protein Modification Process Protein Serine Kinase Activity Immune System Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Regulation Of Immune Response Nucleus Transferase Activity Protein Metabolic Process Kinase Activity Regulation Of Innate Immune Response Intracellular Signaling Cassette Cytoplasm Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process	Chromatin Organization Chromatin Remodeling Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Chromosome Positive Regulation Of Biosynthetic Process Histone Binding Histone Methyltransferase Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Histone H3K4 Monomethyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Transcription Coactivator Activity Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Histone H3 Methyltransferase Activity Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Metaphase Plate Congression Histone H3K4 Methyltransferase Activity Methylation Methyltransferase Activity Acetyltransferase Activity
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