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CHUK and BCL3
Number of citations of the paper that reports this interaction (PubMedID
28689659
)
39
Data Source:
BioGRID
(enzymatic study)
CHUK
BCL3
Description
component of inhibitor of nuclear factor kappa B kinase complex
BCL3 transcription coactivator
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Midbody
Protein-containing Complex
Bcl3-Bcl10 Complex
Bcl3/NF-kappaB2 Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Histone Deacetylase Binding
DNA-binding Transcription Factor Binding
Biological Process
Pattern Recognition Receptor Signaling Pathway
Skeletal Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Immune Response
Canonical NF-kappaB Signal Transduction
Response To Xenobiotic Stimulus
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Cholecystokinin
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Negative Regulation Of Cytokine Production
Follicular Dendritic Cell Differentiation
Marginal Zone B Cell Differentiation
Humoral Immune Response Mediated By Circulating Immunoglobulin
Germinal Center Formation
Protein Import Into Nucleus
Apoptotic Process
Response To Stress
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Response To UV-C
Positive Regulation Of Gene Expression
Antimicrobial Humoral Response
Extracellular Matrix Organization
DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-10 Production
T-helper 1 Type Immune Response
Defense Response To Bacterium
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Defense Response To Protozoan
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
T-helper 2 Cell Differentiation
Positive Regulation Of Translation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Spleen Development
Regulation Of DNA Binding
Response To Other Organism
T Cell Apoptotic Process
Negative Regulation Of T Cell Apoptotic Process
Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Aminosalicylic acid
Mesalazine
Acetylcysteine
Diseases
Cocoon syndrome
GWAS
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Type 2 diabetes (
30054458
)
Alzheimer's disease (
24755620
30636644
)
Alzheimer's disease (late onset) (
23565137
)
Alzheimer's disease (onset between ages 58 and 79) (
30979435
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or fasting insulin levels (pleiotropy) (
30805717
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Asthma (
32296059
)
Body mass index (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x age interaction (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
27863252
)
HDL cholesterol levels (
32203549
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels (
30698716
)
LDL cholesterol levels in current drinkers (
30698716
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Interacting Genes
85 interacting genes:
AKT1
AKT2
AMBRA1
ATM
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C1
H3C14
HECTD3
HSP90AA1
HSP90AB1
HTT
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
MYC
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SAMHD1
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
TTC3
UBC
UBE2E3
UBE2I
UBE2N
35 interacting genes:
AKT1
ANKRD28
BARD1
CHUK
COPS5
CREBBP
CTBP1
CTBP2
CTNNB1
EP300
FOS
FYN
GSK3A
GSK3B
GTF2A1
GTF2B
HDAC1
HDAC3
HDAC6
JUN
KAT5
MAPK1
MAPK3
MAPRE1
N4BP2
NCOA1
NFKB1
NFKB2
PIR
RAB9A
RUVBL2
RXRA
SHC1
TBP
TRAF6
Entrez ID
1147
602
HPRD ID
02811
00179
Ensembl ID
ENSG00000213341
ENSG00000069399
Uniprot IDs
O15111
B7Z3N9
P20749
PDB IDs
3BRT
5EBZ
5TQW
5TQX
5TQY
1K1A
1K1B
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytosol
Nucleoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Apoptotic Process
Protein Modification Process
Protein Serine Kinase Activity
Immune System Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Nucleus
Transferase Activity
Protein Metabolic Process
Kinase Activity
Regulation Of Innate Immune Response
Intracellular Signaling Cassette
Cytoplasm
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Biosynthetic Process
Response To Lipid
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Regulator Complex
Intracellular Signal Transduction
Regulation Of Gene Expression
Nucleoplasm
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Transcription By RNA Polymerase II
Cytosol
Enzyme Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of RNA Metabolic Process
Intracellular Signaling Cassette
Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Chromatin Binding
Nucleus
Regulation Of Macromolecule Metabolic Process
Nucleic Acid Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Transcription Coregulator Binding
Tau Protein Binding
Regulation Of Apoptotic Process
Transcription Corepressor Binding
Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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