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CHUK and MAP3K11
Number of citations of the paper that reports this interaction (PubMedID
10713178
)
74
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vivo)
CHUK
MAP3K11
Description
component of inhibitor of nuclear factor kappa B kinase complex
mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine Kinase Activity
Biological Process
Pattern Recognition Receptor Signaling Pathway
Skeletal Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Immune Response
Canonical NF-kappaB Signal Transduction
Response To Xenobiotic Stimulus
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Cholecystokinin
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
MAPK Cascade
Protein Phosphorylation
Microtubule-based Process
JNK Cascade
Positive Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Cell Cycle G1/S Phase Transition
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
CDC42 GTPase cycle
RHOG GTPase cycle
RHOV GTPase cycle
Signaling downstream of RAS mutants
Drugs
Aminosalicylic acid
Mesalazine
Acetylcysteine
Fostamatinib
Diseases
Cocoon syndrome
GWAS
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Type 2 diabetes (
30054458
)
Acne (severe) (
24927181
30542056
)
Coronary artery disease (
29212778
)
Eosinophil count (
27863252
)
Estimated glomerular filtration rate (
31015462
)
Gout (
25646370
)
Mean platelet volume (
27863252
)
Refractive error (
32231278
)
Serum uric acid levels (
32514006
)
Sum eosinophil basophil counts (
27863252
)
Type 2 diabetes (
28566273
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
85 interacting genes:
AKT1
AKT2
AMBRA1
ATM
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C1
H3C14
HECTD3
HSP90AA1
HSP90AB1
HTT
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
MYC
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SAMHD1
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
TTC3
UBC
UBE2E3
UBE2I
UBE2N
29 interacting genes:
AKT1
APP
CDC42
CHUK
CLEC4G
COPS5
DSCAM
EPS8
IKBKB
KIF17
KIF3A
KIF3B
KIFAP3
LATS1
MAP2K4
MAP2K7
MAP3K12
MAP3K21
MAP4K1
MAP4K2
MAPK8IP1
MAPK8IP2
MAPK8IP3
PIN1
RAC1
RHOG
SH3RF1
STUB1
TRAF6
Entrez ID
1147
4296
HPRD ID
02811
02502
Ensembl ID
ENSG00000213341
ENSG00000173327
Uniprot IDs
O15111
Q16584
PDB IDs
3BRT
5EBZ
5TQW
5TQX
5TQY
5K26
5K28
6AQB
6CQ7
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytosol
Nucleoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Apoptotic Process
Protein Modification Process
Protein Serine Kinase Activity
Immune System Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Nucleus
Transferase Activity
Protein Metabolic Process
Kinase Activity
Regulation Of Innate Immune Response
Intracellular Signaling Cassette
Cytoplasm
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signaling Cassette
MAPK Cascade
Intracellular Signal Transduction
Regulation Of JNK Cascade
Regulation Of MAPK Cascade
JNK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Postsynapse
Positive Regulation Of MAPK Cascade
Positive Regulation Of JNK Cascade
Positive Regulation Of Signal Transduction
Protein Serine/threonine Kinase Activity
Nucleotide Binding
Kinesin II Complex
MAP-kinase Scaffold Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Axo-dendritic Transport
Protein Kinase Binding
Protein Serine Kinase Activity
Regulation Of Apoptotic Process
Protein Kinase Activity
Transport Along Microtubule
Regulation Of Programmed Cell Death
Signal Transduction
Glutamatergic Synapse
Cytoskeleton-dependent Intracellular Transport
Fc-epsilon Receptor Signaling Pathway
Plus-end-directed Vesicle Transport Along Microtubule
Regulation Of Signal Transduction
ATP Binding
Microtubule-based Transport
Kinase Activity
Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Plus-end-directed Organelle Transport Along Microtubule
Regulation Of Postsynapse Organization
Cell Projection Organization
CD40 Receptor Complex
Anterograde Dendritic Transport
JUN Kinase Binding
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Phosphorylation
Photoreceptor Connecting Cilium
Kinesin Binding
Kinesin Complex
Establishment Of Vesicle Localization
Cytoplasm
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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