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CHUK and NCOR2
Number of citations of the paper that reports this interaction (PubMedID
16382138
)
72
Data Source:
BioGRID
(enzymatic study, enzymatic study)
HPRD
(in vitro)
CHUK
NCOR2
Description
component of inhibitor of nuclear factor kappa B kinase complex
nuclear receptor corepressor 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Chromatin
Nucleus
Nucleoplasm
Membrane
Nuclear Matrix
Nuclear Body
Transcription Repressor Complex
Protein-containing Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Notch Binding
Protein Binding
Enzyme Activator Activity
Nuclear Receptor Binding
Nuclear Glucocorticoid Receptor Binding
Histone Deacetylase Binding
Nuclear Retinoic Acid Receptor Binding
Protein-containing Complex Binding
Nuclear Retinoid X Receptor Binding
Biological Process
Pattern Recognition Receptor Signaling Pathway
Skeletal Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Immune Response
Canonical NF-kappaB Signal Transduction
Response To Xenobiotic Stimulus
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Cholecystokinin
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Negative Regulation Of Transcription By RNA Polymerase II
Lactation
Regulation Of Ketone Metabolic Process
Cerebellum Development
Response To Estradiol
Estrous Cycle
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of MiRNA Transcription
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Cytoprotection by HMOX1
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Aminosalicylic acid
Mesalazine
Acetylcysteine
Diseases
Cocoon syndrome
GWAS
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Type 2 diabetes (
30054458
)
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) (
23648065
)
Appendicular lean mass (
33097823
)
Clubfoot (
24667120
)
Cocaine dependence (
23958962
)
Cognitive performance (
19734545
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Lung function (FEV1) (
30061609
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Mosquito bite size (
28199695
)
Multiple sclerosis (
31604244
)
Platelet distribution width (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
85 interacting genes:
AKT1
AKT2
AMBRA1
ATM
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C1
H3C14
HECTD3
HSP90AA1
HSP90AB1
HTT
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
MYC
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SAMHD1
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
TTC3
UBC
UBE2E3
UBE2I
UBE2N
92 interacting genes:
ADRB2
AHR
AKT1
AP2M1
AR
ARNT
ATXN1
ATXN1L
BCL6
C1D
CAMK2B
CBFA2T2
CDK2
CEBPB
CEP63
CHUK
CIRSR
CNOT2
DDX20
E2F1
ESR1
ESR2
FOS
FOXP1
H4C1
HDAC1
HDAC10
HDAC3
HDAC4
HDAC5
HDAC7
HNF4A
INPP5K
IRF5
JUN
KLF5
KPNA4
MYBL2
MYOD1
NCOA3
NCOA6
NCOR1
NFE2L2
NFKB1
NFKBIA
NFKBIB
NFKBIE
NR1D1
NR1H2
NR1H4
NR1I2
NR2F1
NR2F2
NR3C1
NR4A1
PIN1
PML
POU2F1
PPARA
PPARD
PPARG
RANBP9
RARA
RARB
RARG
RBPJ
RELA
RUNX1
RUNX1T1
RXRA
RXRG
SAP30
SKIL
SNW1
SP1
SPEN
SRF
STAT5A
STAT5B
SUMO1
TBL1X
THRA
THRB
TNIK
TNIP2
UBC
UBE2I
VDR
YWHAE
ZBTB16
ZBTB5
ZBTB7A
Entrez ID
1147
9612
HPRD ID
02811
02910
Ensembl ID
ENSG00000213341
ENSG00000196498
Uniprot IDs
O15111
C9J0Q5
C9JE98
Q9Y618
PDB IDs
3BRT
5EBZ
5TQW
5TQX
5TQY
1KKQ
1R2B
1XC5
2GPV
2L5G
2LTP
2ODD
2RT5
3R29
3R2A
4A69
4OAR
5X8Q
5X8X
5ZOO
5ZOP
6A22
6IVX
6PDZ
7SQA
8AQM
8AQN
8B8W
8B8X
8B8Y
8B8Z
8B90
8B91
8B92
8B93
8B94
8B95
8X7E
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytosol
Nucleoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Apoptotic Process
Protein Modification Process
Protein Serine Kinase Activity
Immune System Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Nucleus
Transferase Activity
Protein Metabolic Process
Kinase Activity
Regulation Of Innate Immune Response
Intracellular Signaling Cassette
Cytoplasm
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Intracellular Receptor Signaling Pathway
DNA-binding Transcription Factor Activity
Sequence-specific DNA Binding
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleus
DNA Binding
Chromatin
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nuclear Receptor-mediated Signaling Pathway
Positive Regulation Of Metabolic Process
RNA Polymerase II Transcription Regulator Complex
DNA-templated Transcription
Hormone-mediated Signaling Pathway
Retinoic Acid Receptor Signaling Pathway
Intracellular Signal Transduction
Cell Differentiation
Transcription Cis-regulatory Region Binding
Regulation Of Multicellular Organismal Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Sequence-specific Double-stranded DNA Binding
Transcription By RNA Polymerase II
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