CHUK and IKBKAP

Number of citations of the paper that reports this interaction (PMID 9751059)
59

Data Source:
HPRD (in vivo, in vitro)

		CHUK	IKBKAP
Gene Name		conserved helix-loop-helix ubiquitous kinase	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Intracellular Membrane-bounded Organelle	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding	RNA Polymerase II Core Binding Signal Transducer Activity Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Skeletal Muscle Contraction Protein Phosphorylation Inflammatory Response Immune Response Epidermal Growth Factor Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Rho Protein Signal Transduction Lactation Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Osteoclast Differentiation Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Hydroperoxide Mammary Gland Epithelial Cell Proliferation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Odontogenesis Of Dentin-containing Tooth Response To Drug Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Mammary Gland Alveolus Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Tumor Necrosis Factor	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Immune Response Signal Transduction Positive Regulation Of Cell Migration Regulation Of Protein Kinase Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Signaling by PDGF DAP12 interactions GAB1 signalosome TRIF-mediated TLR3/TLR4 signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins TCR signaling Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling PI3K/AKT Signaling in Cancer TAK1 activates NFkB by phosphorylation and activation of IKKs complex Adaptive Immune System Downstream TCR signaling PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs PI3K events in ERBB2 signaling Downstream signaling of activated FGFR TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Signaling by FGFR RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Liver enzyme levels ( 18940312)
Protein-Protein Interactions		75 interactors: AKT1 AKT2 BCL10 BTRC CASP8 CDC37 CHEK1 COPS5 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 EIF2AK2 ERBB2IP ESR1 FKBP5 FOXO3 HIST2H3C HIST3H3 HSP90AA1 HSP90AB1 HTT IKBKAP IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TNIP2 TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP UBE2E3 UBE2I UBE2N	26 interactors: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9
Entrez ID		1147	8518
HPRD ID		02811	04763
Ensembl ID		ENSG00000213341	ENSG00000070061
Uniprot IDs		O15111	O95163 Q8N516
PDB IDs		3BRT
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Signal Transduction Positive Regulation Of Cellular Metabolic Process Immune System Process Signaling Defense Response Positive Regulation Of Metabolic Process Cell Communication Regulation Of Signal Transduction Regulation Of Innate Immune Response Cellular Response To Organic Substance Regulation Of Signaling Regulation Of Immune Response Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Toll-like Receptor 3 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Death Death Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Response To Stress	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To External Stimulus Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Fc Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Acetylation Antigen Receptor-mediated Signaling Pathway Histone H3 Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Signal Transduction Negative Regulation Of Cell Death Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Type I Interferon Production
Tagcloud ?		accentuated analog analogs antineoplastic attributes coincided confined correspond cyclooxygenase encountered govern implying instance krox microtubule modulates oligoadenylate oncology originate prompts questions simply stabilization taxane taxol taxotere termed traits unidentified	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Difference) ?		accentuated analog analogs antineoplastic attributes coincided confined correspond cyclooxygenase encountered govern implying instance krox microtubule modulates oligoadenylate oncology originate prompts questions simply stabilization taxane taxol taxotere termed traits unidentified	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Intersection) ?