CHUK and PAX8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CHUK	PAX8
Description		component of inhibitor of nuclear factor kappa B kinase complex	paired box 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Contraction Regulation Of Transcription By RNA Polymerase II Inflammatory Response Immune Response Canonical NF-kappaB Signal Transduction Response To Xenobiotic Stimulus Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Response To Acetate Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interferon-alpha Production Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Cholecystokinin Cellular Response To Tumor Necrosis Factor Cellular Response To Virus	Urogenital System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Sensory Organ Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development S-shaped Body Morphogenesis Kidney Epithelium Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	Formation of intermediate mesoderm Formation of the nephric duct
Drugs		Aminosalicylic acid Mesalazine Acetylcysteine
Diseases		Cocoon syndrome	Congenital nongoitrous hypothyroidism (CHNG) Thyroid cancer
GWAS		Liver enzyme levels ( 18940312) Psoriasis ( 28537254) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Type 2 diabetes ( 30054458)	Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Cervical intraepithelial neoplasia grade 3 ( 33794208) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Language functional connectivity ( 34929384) Lymphocyte count ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		85 interacting genes: AKT1 AKT2 AMBRA1 ATM ATR BCL10 BCL3 BTRC CASP8 CDC37 CHEK1 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 DCUN1D5 E2F4 EIF2AK2 ELP1 ERBIN ESR1 FKBP5 FOXO3 H3-4 H3C1 H3C14 HECTD3 HSP90AA1 HSP90AB1 HTT IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 MYC NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SAMHD1 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP TTC3 UBC UBE2E3 UBE2I UBE2N	24 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HNF1B HOXC8 HOXC9 ID2 LONRF1 NFIC NFIX NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SMAD3 SS18L1 WBP2
Entrez ID		1147	7849
HPRD ID		02811	01335
Ensembl ID		ENSG00000213341	ENSG00000125618
Uniprot IDs		O15111	Q06710 R9W7C9
PDB IDs		3BRT 5EBZ 5TQW 5TQX 5TQY	2K27
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytosol Nucleoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Apoptotic Process Protein Modification Process Protein Serine Kinase Activity Immune System Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Regulation Of Immune Response Nucleus Transferase Activity Protein Metabolic Process Kinase Activity Regulation Of Innate Immune Response Intracellular Signaling Cassette Cytoplasm Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Animal Organ Morphogenesis Regulation Of Primary Metabolic Process Chromatin Pattern Specification Process Positive Regulation Of Metabolic Process Regionalization Anterior/posterior Pattern Specification Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thigmotaxis Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Endoderm Development Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Organ Morphogenesis DNA-binding Transcription Factor Activity Gland Development Mesonephric Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Mesonephric Epithelium Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Tube Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Kidney Epithelium Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Virus Developmental Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Differentiation Response To Virus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding
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