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CHUK and NOTCH3
Number of citations of the paper that reports this interaction (PubMedID
17289033
)
0
Data Source:
HPRD
(in vivo)
CHUK
NOTCH3
Description
component of inhibitor of nuclear factor kappa B kinase complex
notch receptor 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Calcium Ion Binding
Protein Binding
Enzyme Binding
Signaling Receptor Activity
Identical Protein Binding
Cadherin Binding
Biological Process
Pattern Recognition Receptor Signaling Pathway
Skeletal Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Immune Response
Canonical NF-kappaB Signal Transduction
Response To Xenobiotic Stimulus
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Cholecystokinin
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Notch Signaling Pathway
Axon Guidance
Neuroblast Differentiation
Cell Differentiation
Neuron Differentiation
Forebrain Development
Negative Regulation Of Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Cell Proliferation
Neuron Fate Commitment
Artery Morphogenesis
Regulation Of Developmental Process
Glomerular Capillary Formation
Positive Regulation Of MiRNA Transcription
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Noncanonical activation of NOTCH3
Drugs
Aminosalicylic acid
Mesalazine
Acetylcysteine
Diseases
Cocoon syndrome
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Type 2 diabetes (
30054458
)
Pulse pressure (
27841878
30578418
)
Toxoplasma gondii sag1 antibody levels (
33204752
)
Interacting Genes
85 interacting genes:
AKT1
AKT2
AMBRA1
ATM
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C1
H3C14
HECTD3
HSP90AA1
HSP90AB1
HTT
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
MYC
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SAMHD1
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
TTC3
UBC
UBE2E3
UBE2I
UBE2N
53 interacting genes:
ANKRD28
BAG2
BTF3L4
C1QL1
C8orf76
CBFA2T2
CHUK
CNTD1
CPNE6
CRIP2
CSNK2B
DLL1
EGFL7
FBLN1
GGT6
HOXA1
JAG1
JAG2
KAT2B
LINC00839
LTBP1
MAML1
MAML2
MAML3
MBD1
MPPED2
MTDH
MYC
NEDD9
NUFIP2
PPIA
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSEN1
PSEN2
RBPJ
RET
RMI2
SCGB3A1
SHANK3
SLC39A1
SNW1
SNX19
SORBS3
SPTLC2
TMEM108
TNNT2
TPT1
WDR25
XKR8
Entrez ID
1147
4854
HPRD ID
02811
02607
Ensembl ID
ENSG00000213341
ENSG00000074181
Uniprot IDs
O15111
Q9UM47
PDB IDs
3BRT
5EBZ
5TQW
5TQX
5TQY
4ZLP
5CZV
5CZX
6WQU
6XSW
8OS0
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytosol
Nucleoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Apoptotic Process
Protein Modification Process
Protein Serine Kinase Activity
Immune System Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Nucleus
Transferase Activity
Protein Metabolic Process
Kinase Activity
Regulation Of Innate Immune Response
Intracellular Signaling Cassette
Cytoplasm
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Notch Binding
Tissue Morphogenesis
Regulation Of Timing Of Cell Differentiation
Regulation Of Notch Signaling Pathway
Regulation Of Development, Heterochronic
MAML1-RBP-Jkappa- ICN1 Complex
Blood Vessel Endothelial Cell Fate Specification
Auditory Receptor Cell Fate Commitment
Tube Morphogenesis
Positive Regulation Of Developmental Process
Endothelial Cell Fate Specification
Morphogenesis Of An Epithelium
Cell Surface Receptor Signaling Pathway
Loop Of Henle Development
Calcium Ion Binding
Neuron Differentiation
Myoblast Differentiation
Negative Regulation Of Viral Life Cycle
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Membrane Protein Proteolysis
Inhibition Of Neuroepithelial Cell Differentiation
Gamma-secretase Complex
Positive Regulation Of Signal Transduction
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Signaling
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Stress-activated MAPK Cascade
Lymphocyte Migration Into Lymphoid Organs
Notch Receptor Processing
Transcription Coactivator Activity
Negative Regulation Of Notch Signaling Pathway
Epithelial Tube Morphogenesis
Positive Regulation Of Kidney Development
Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade
Amyloid-beta Formation
Somitogenesis
Anatomical Structure Morphogenesis
Cognition
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Signal Transduction
Stem Cell Population Maintenance
Endothelial Tube Morphogenesis
Segmentation
Maintenance Of Cell Number
Positive Regulation Of Cellular Component Organization
Nephron Development
Inner Ear Development
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Tagcloud (Difference)
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Tagcloud (Intersection)
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