HTR6 and SYT5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	SYT5
Description		5-hydroxytryptamine receptor 6	synaptotagmin 5
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Endosome Plasma Membrane Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Protein Heterodimerization Activity Calcium Ion Sensor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Exocytosis
Pathways		Serotonin receptors G alpha (s) signalling events	Regulation of insulin secretion
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	7 interacting genes: DNAJC5 HTR6 NRXN1 POLR2E RAB1A SHANK3 SYT3
Entrez ID		3362	6861
HPRD ID		03066	02870
Ensembl ID		ENSG00000158748	ENSG00000129990
Uniprot IDs		P50406	O00445 Q4FD32
PDB IDs		7XTB 7YS6 8JLZ	5H4Y 5H4Z
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Guanylate Kinase-associated Protein Clustering NMDA Glutamate Receptor Clustering Vocal Learning Observational Learning Neurotransmitter-gated Ion Channel Clustering Auditory Behavior Mechanosensory Behavior Vocalization Behavior Signal Release Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Nervous System Development Transport Vesicle Membrane Receptor Clustering Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Epiboly Involved In Gastrulation With Mouth Forming Second Plasma Membrane Bounded Cell Projection Organization Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Social Behavior Synapse Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Secretion By Cell Regulation Of Nervous System Development Cell Projection Organization Melanosome Protein Complex Involved In Cell-cell Adhesion Synapse Assembly Positive Regulation Of Cellular Component Organization Neuron Projection Development Neuromuscular Process Fasciculation Of Sensory Neuron Axon Secretion Vesicle Localization Regulation Of Nervous System Process Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Central Nervous System Neuron Differentiation Negative Regulation Of Filopodium Assembly Synaptic Receptor Adaptor Activity Positive Regulation Of Developmental Process
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