HTR6 and ABCA2

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		HTR6	ABCA2
Name		5-hydroxytryptamine receptor 6	ATP binding cassette subfamily A member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle ATP-binding Cassette (ABC) Transporter Complex Intracellular Membrane-bounded Organelle
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	Nucleotide Binding Lipid Transporter Activity ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Endopeptidase Regulator Activity Ceramide Floppase Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Ganglioside Metabolic Process Lipid Metabolic Process Sphingomyelin Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Locomotory Behavior Response To Xenobiotic Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Steroid Metabolic Process Central Nervous System Myelin Formation Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Sphingosine Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Protein Metabolic Process Transmembrane Transport Regulation Of Protein Glycosylation Response To Cholesterol Negative Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Cholesterol Efflux Ceramide Translocation Transport Across Blood-brain Barrier Regulation Of Post-translational Protein Modification Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein Localization To Cell Surface
Pathways		Serotonin receptors G alpha (s) signalling events	ABC transporters in lipid homeostasis
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil	None
GWAS		Chronotype ( 26955885 27494321 ) Morning person ( 30696823 ) Morning vs. evening chronotype ( 26955885 27494321 )	Adverse response to drug ( 30420678 ) Cutaneous mastocytosis ( 32752121 ) Cutaneous mastocytosis (adult) ( 32752121 ) Cutaneous mastocytosis (childhood) ( 32752121 ) Mastocytosis ( 32752121 ) Systemic mastocytosis ( 32752121 ) White blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: CD160	None recorded
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	8 interacting genes: CACNA1A CDK5RAP2 DRD2 DYRK1A HTR6 LCOR RSPH1 RUNX1
Entrez ID		3362	20
HPRD ID		03066	08967
Ensembl ID		ENSG00000158748	ENSG00000107331
Uniprot IDs		P50406	Q9BZC7
PDB IDs		7XTB 7YS6 8JLZ	Not available
GO Terms Enriched among Interactors		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Transcription Corepressor Binding Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Microtubule Polymerization Tubulin Binding Histone H3T45 Kinase Activity Signaling Cell Communication Cell-cell Signaling Calcium Ion Transmembrane Import Into Cytosol Cardiac Muscle Tissue Regeneration Core-binding Factor Complex Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Sperm Flagellum Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dendrite G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Response To Estradiol Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Circadian Rhythm Cilium Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Microtubule Bundle Formation