HTR6 and SRRT

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	SRRT
Description		5-hydroxytryptamine receptor 6	serrate, RNA effector molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Nucleus Nucleoplasm Cytoplasm Nuclear Body Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity MRNA Cap Binding Complex Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Neuronal Stem Cell Population Maintenance
Pathways		Serotonin receptors G alpha (s) signalling events	RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway Nuclear RNA decay
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Hemoglobin levels ( 32327693) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 27798624) RR interval (heart rate) ( 30679814)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	16 interacting genes: APP CACNA1C CHD3 CSNK2A1 GEMIN4 GIT1 HNRNPK HSPA8 HTR6 IMMT LINC00624 SNRPF STAT3 SUMO2 VAV2 VIM
Entrez ID		3362	51593
HPRD ID		03066	10665
Ensembl ID		ENSG00000158748	ENSG00000087087
Uniprot IDs		P50406	Q9BXP5
PDB IDs		7XTB 7YS6 8JLZ	5OO6 6F7J 6F7P 6F7S 6F8D 8PMP
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Regulation Of Protein Import Regulation Of Glycolytic Process MRNA Metabolic Process Regulation Of Carbohydrate Catabolic Process RNA Binding Negative Regulation Of Inflammatory Response To Wounding Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Inflammatory Response To Wounding Protein Targeting To Vacuole Involved In Autophagy Regulation Of Interleukin-1 Beta Production Small Nuclear Ribonucleoprotein Complex Positive Regulation Of Catabolic Process SMN-Sm Protein Complex Regulation Of Interleukin-1 Production PML Body Negative Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of ATP Metabolic Process RNA Splicing Astrocyte Differentiation Positive Regulation Of ATP Metabolic Process Spliceosomal Complex Focal Adhesion MRNA Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Dendrite Amylin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll Signaling Pathway RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Chaperone-mediated Autophagy Translocation Complex Disassembly Spliceosomal SnRNP Assembly Negative Regulation Of ARF Protein Signal Transduction Protein Targeting To Vacuole Regulation Of Biological Quality RNA Metabolic Process Presynapse Postsynapse Regulation Of Cellular Response To Stress Positive Regulation Of Interleukin-1 Beta Production Acetylcholine Receptor Activator Activity Regulation Of Multicellular Organism Growth Lipoprotein Particle Positive Regulation Of Protein Import
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