HTR6 and IDS

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	IDS
Description		5-hydroxytryptamine receptor 6	iduronate 2-sulfatase
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Lysosome Lysosomal Lumen
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	Iduronate-2-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Carbohydrate Derivative Catabolic Process
Pathways		Serotonin receptors G alpha (s) signalling events	HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome (HS-GAG degradation) MPS II - Hunter syndrome (CS/DS degradation)
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Mucopolysaccharidosis type II (MPS2); Hunter syndrome
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Cognitive performance ( 20125193) Idiopathic downbeat nystagmus ( 32157568)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	4 interacting genes: FTCD HTR6 LCOR RUNX1
Entrez ID		3362	3423
HPRD ID		03066	02402
Ensembl ID		ENSG00000158748	ENSG00000010404
Uniprot IDs		P50406	B4DGD7 P22304
PDB IDs		7XTB 7YS6 8JLZ	5FQL 6IOZ
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Transcription Corepressor Binding Proteasome Core Complex Assembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide
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