HTR6 and HDGFL2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	HDGFL2
Description		5-hydroxytryptamine receptor 6	HDGF like 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Nucleus Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	Protein Binding Histone H3K27me3 Reader Activity Histone H3K9me2/3 Reader Activity Histone Reader Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Muscle Organ Development Positive Regulation Of Cell Growth Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Serotonin receptors G alpha (s) signalling events
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	6 interacting genes: AGTR1 H3C14 HTR2B HTR6 TERF1 TERF2
Entrez ID		3362	84717
HPRD ID		03066	13639
Ensembl ID		ENSG00000158748	ENSG00000167674
Uniprot IDs		P50406	Q7Z4V5
PDB IDs		7XTB 7YS6 8JLZ	3EAE 3QBY 3QJ6 6T3I 7HG0 7HG1 7HG2 7HG3 7HG4 7HG5 7HG6 7HG7 7HG8 7HG9 7HGA 7HGB 7HGC 7HGD 7HGE 7HGF 7HGG 7HGH 7HGI 7HGJ 7HGK 7HGL 7HGM 7HGN 7HGO 7HGP 7HGQ 7HGR 7HGS 7HGT 7HGU 7HGV 7HGW 7HGX 7HGY 7HGZ 7HH0 7HH1 7HH2 7HH3 7HH4 7HH5 7HH6 7HH7 7HH8 7HH9 7HHA 7HHB 7HHC 7HHD 7HHE 7HHF 7HHG 7HHH 7HHI 7HHJ 7HHK 7HHL 7HHM 7HHN 7HHO 7HHP 7HHQ 7HHR 9G91 9G94 9G96 9GRS 9GRT 9GRU 9GRV
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Serotonin Receptor Signaling Pathway G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Serotonin Receptor Activity Telomere Capping G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Receptor Activity Angiotensin Type I Receptor Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Proliferation Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Bradykinin Receptor Binding Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Lipid Metabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway
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