HTR6 and DDRGK1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	DDRGK1
Description		5-hydroxytryptamine receptor 6	DDRGK domain containing 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	Protein Binding Ubiquitin-like Protein Ligase Binding UFM1-modified Protein Reader Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Reticulophagy Protein Localization To Endoplasmic Reticulum Protein Ufmylation Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum Protein K69-linked Ufmylation
Pathways		Serotonin receptors G alpha (s) signalling events	RHOA GTPase cycle
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	HDL cholesterol levels x loop diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to hepatitis C treatment ( 21659334) Ribavirin-induced anemia ( 20637204)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	6 interacting genes: APP CFTR FBXO7 HTR6 KEAP1 TP53
Entrez ID		3362	65992
HPRD ID		03066	12741
Ensembl ID		ENSG00000158748	ENSG00000198171
Uniprot IDs		P50406	Q96HY6
PDB IDs		7XTB 7YS6 8JLZ	7W3N 8B9X 8C0D 8OHD 8OJ0 8OJ5
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Protein-containing Complex Protein-folding Chaperone Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Molecular Function Activator Activity Disordered Domain Specific Binding 14-3-3 Protein Binding Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Enzyme Binding Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Protein Heterodimerization Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Autophagy Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process Response To CAMP Protein Tetramerization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Developmental Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium
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