HTR6 and SLC6A1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	SLC6A1
Description		5-hydroxytryptamine receptor 6	solute carrier family 6 member 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Plasma Membrane Cell Surface Membrane Axon Cell Projection Neuronal Cell Body Synapse Presynapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	Amino Acid:sodium Symporter Activity Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Protein Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Amino Acid Transmembrane Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Memory Associative Learning Sodium Ion Transmembrane Transport Synapse Organization Gamma-aminobutyric Acid Reuptake Gamma-aminobutyric Acid Import Inorganic Anion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Neurotransmitter Reuptake Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		Serotonin receptors G alpha (s) signalling events	SLC-mediated transport of neurotransmitters Reuptake of GABA
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil	Tiagabine Guvacine
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Body fat percentage ( 31752434) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Loneliness (linear analysis) ( 27629369) Longitudinal alcohol consumption ( 26081443) Lung function ( 31902109) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	7 interacting genes: ARFGAP1 DRD2 HSF2BP HTR6 HUNK SNCA STX1A
Entrez ID		3362	6529
HPRD ID		03066	00664
Ensembl ID		ENSG00000158748	ENSG00000157103
Uniprot IDs		P50406	A0A2R8Y4I3 B7Z3C5 P30531
PDB IDs		7XTB 7YS6 8JLZ	7SK2 7Y7V 7Y7W 7Y7Y 7Y7Z
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Regulation Of Amine Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Synaptic Transmission, Dopaminergic Synapse Synaptic Vesicle Membrane Behavioral Response To Cocaine Dopamine Transport Neurotransmitter Reuptake Positive Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Regulation Of Dopamine Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Vesicle-mediated Transport Monoamine Transport Neurotransmitter Uptake Dopamine Metabolic Process Response To Iron Ion Synaptic Vesicle Exocytosis Synaptic Vesicle Endocytosis Telencephalon Cell Migration Response To Cocaine Catecholamine Metabolic Process Presynaptic Endocytosis Forebrain Cell Migration Positive Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Axon Terminus Regulation Of Endocytosis Positive Regulation Of Secretion Excitatory Postsynaptic Potential Trans-synaptic Signaling Biogenic Amine Metabolic Process Synaptic Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Myosin Head/neck Binding Receptor Internalization
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