HTR6 and PARP8

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR6	PARP8
Description		5-hydroxytryptamine receptor 6	poly(ADP-ribose) polymerase family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Dendrite Synapse	Nuclear Envelope Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity	NAD+ Poly-ADP-ribosyltransferase Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Kinase Binding Protein Serine/threonine Kinase Activator Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Endoplasmic Reticulum Unfolded Protein Response Protein Auto-ADP-ribosylation
Pathways		Serotonin receptors G alpha (s) signalling events	Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Callous-unemotional behaviour ( 23874384) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood ear infection ( 27182965) General risk tolerance (MTAG) ( 30643258) HOMA-B (corrected for HOMA-IR) ( 30369944) Myopia (pathological) ( 22685421) Type 2 diabetes ( 30718926 32499647) Verbal declarative memory ( 25648963)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	1 interacting genes: HTR6
Entrez ID		3362	79668
HPRD ID		03066	07960
Ensembl ID		ENSG00000158748	ENSG00000151883
Uniprot IDs		P50406	B2RB27 E9PFI7 Q8N3A8
PDB IDs		7XTB 7YS6 8JLZ
Enriched GO Terms of Interacting Partners?		Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH	Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Histamine Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cerebral Cortex Cell Migration Forebrain Cell Migration Telencephalon Cell Migration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of TOR Signaling Regulation Of TOR Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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