EPB41L3 and CNTNAP2

Number of citations of the paper that reports this interaction (PMID 12542678)
29

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EPB41L3	CNTNAP2
Gene Name		erythrocyte membrane protein band 4.1-like 3	contactin associated protein-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Extrinsic Component Of Membrane Axolemma Paranode Region Of Axon Juxtaparanode Region Of Axon	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding	Enzyme Binding
	Biological Process	Protein Localization To Paranode Region Of Axon Apoptotic Process Cytoskeletal Anchoring At Plasma Membrane Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Cellular Protein Localization Social Behavior Clustering Of Voltage-gated Potassium Channels Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 22159054) Bipolar disorder and schizophrenia ( 20889312) Body mass index (interaction) ( 23192594) Bone mineral density ( 17903296) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		17 interactors: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 IGSF21 MBIP PAXIP1 PSEN1 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ	8 interactors: CASK CNTN2 CTR9 EPB41L3 KCNA2 MACF1 MEOX2 ZMIZ1
Entrez ID		23136	26047
HPRD ID		05622	05197
Ensembl ID		ENSG00000082397	ENSG00000174469
Uniprot IDs		A8K968 B7Z4I5 F5GX05 Q9Y2J2	B2RCH4 Q9UHC6
PDB IDs		2HE7 3BIN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Nervous System Development Regulation Of Protein Localization Cellular Localization Membrane Organization System Development Cellular Protein Localization Protein Localization Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell Apoptotic Process Establishment Of Protein Localization Programmed Cell Death Intracellular Transport Apoptotic Signaling Pathway Cell Death Death Multicellular Organismal Development Regulation Of Synaptic Plasticity Anatomical Structure Development Brain Development Head Development Positive Regulation Of Signal Transduction Intracellular Signal Transduction Cellular Component Assembly Developmental Process Regulation Of Apoptotic Process Central Nervous System Development Regulation Of Cell Death Generation Of Neurons Regulation Of Synaptic Transmission	Anatomical Structure Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Multicellular Organismal Development Anatomical Structure Development Developmental Process System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Embryo Development Establishment Of Protein Localization To Juxtaparanode Region Of Axon Regulation Of Cell Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Adenosine Receptor Signaling Pathway Optic Nerve Structural Organization Vitellogenesis Positive Regulation Of Histone H3-K79 Methylation Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Biosynthetic Process Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Gene Expression Myelination Protein Localization To Plasma Membrane Axon Ensheathment Positive Regulation Of Cellular Biosynthetic Process Regulation Of Axonogenesis Gastrulation Regulation Of Cell-substrate Adhesion Protein Localization To Paranode Region Of Axon Somite Specification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Axon Diameter Membrane Organization Plasma Membrane Organization Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Posttranslational Protein Targeting To Membrane Cytoplasm Organization Cerebral Cortex GABAergic Interneuron Migration Histone H2B Ubiquitination Regulation Of Cell Projection Size Interneuron Migration From The Subpallium To The Cortex Optic Nerve Morphogenesis Presynaptic Membrane Organization Wnt Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Negative Regulation Of Keratinocyte Proliferation Neuronal Ion Channel Clustering Paranodal Junction Assembly
Tagcloud ?			acutely ameliorate asd autism cdfe contactin deficit deficits designer displays dreadd dysregulation epilepsy exclusively homolog hypothalamus immunoreactive knockout lasting melanocortin neuropeptide neuropsychiatric oxytocin paraventricular penetrance pvn rectify rescued windows
Tagcloud (Difference) ?			acutely ameliorate asd autism cdfe contactin deficit deficits designer displays dreadd dysregulation epilepsy exclusively homolog hypothalamus immunoreactive knockout lasting melanocortin neuropeptide neuropsychiatric oxytocin paraventricular penetrance pvn rectify rescued windows
Tagcloud (Intersection) ?