ACTG1 and DNASE1

Number of citations of the paper that reports this interaction (PMID 11474115)
128

Data Source:
HPRD (in vitro)

		ACTG1	DNASE1
Gene Name		actin gamma 1	deoxyribonuclease I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Nucleus Nuclear Envelope Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Actin Binding Endodeoxyribonuclease Activity Deoxyribonuclease I Activity Protein Binding
	Biological Process	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation	DNA Catabolic Process, Endonucleolytic Apoptotic Process
Pathways		Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1	4 interactors: ACTA1 ACTA2 ACTB ACTG1
Entrez ID		71	1773
HPRD ID		00017	00509
Ensembl ID		ENSG00000184009
Uniprot IDs		P63261	P24855
PDB IDs			4AWN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction	Platelet Aggregation Cell Development Response To External Stimulus Retina Homeostasis Myofibril Assembly Adherens Junction Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Striated Muscle Cell Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Muscle Cell Development Skeletal Muscle Fiber Adaptation Tissue Homeostasis Platelet Activation Cell Junction Assembly Cell Differentiation Cell-cell Junction Organization Muscle Contraction Striated Muscle Cell Differentiation Multicellular Organismal Homeostasis Muscle System Process Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Glomerular Mesangial Cell Development Movement Of Cell Or Subcellular Component System Development Mesangial Cell Development Skeletal Muscle Thin Filament Assembly Muscle Cell Differentiation Homotypic Cell-cell Adhesion Renal Interstitial Fibroblast Development Skeletal Myofibril Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Skeletal Muscle Adaptation Axon Guidance Multicellular Organismal Development Blood Coagulation Anatomical Structure Development Hemostasis Cellular Component Assembly Vascular Smooth Muscle Contraction Immune Response-regulating Signaling Pathway Organelle Assembly Muscle Structure Development Single Organismal Cell-cell Adhesion Axonogenesis
Tagcloud ?		alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	chip crx dhs distinguish epigenetic essentially genome great h3k27me3 h3k4me2 hypersensitive identifying maps merged novo photoreceptor pol probability reflective retina retinal rod seq sets signature signatures striking unbiased widespread
Tagcloud (Difference) ?		alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	chip crx dhs distinguish epigenetic essentially genome great h3k27me3 h3k4me2 hypersensitive identifying maps merged novo photoreceptor pol probability reflective retina retinal rod seq sets signature signatures striking unbiased widespread
Tagcloud (Intersection) ?