ACTG1 and LSP1

Number of citations: 0 (PubMedID 10925289)
Data Source: HPRD (in vitro)

		ACTG1	LSP1
Name		actin gamma 1	lymphocyte specific protein 1
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Myofibril Axon Filamentous Actin NuA4 Histone Acetyltransferase Complex Apical Junction Complex Calyx Of Held Apical Part Of Cell Synapse Phagocytic Vesicle Extracellular Exosome Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Basal Body Patch	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Hydrolase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	Actin Binding Protein Binding
	Biological Process	Angiogenesis Morphogenesis Of A Polarized Epithelium Axonogenesis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Sarcomere Organization Cell Motility Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Platelet Aggregation Cellular Response To Type II Interferon Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Protein Localization To Bicellular Tight Junction	Chemotaxis Defense Response Cellular Defense Response Signal Transduction Cellular Response To Interleukin-7
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	None
Drugs		Copper Artenimol	None
GWAS		Alanine aminotransferase levels ( 33339817 33547301 ) Gamma glutamyl transferase levels ( 33339817 ) Hand grip strength ( 29313844 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Refractive error ( 32231278 )	Bladder cancer ( 24163127 ) Breast cancer ( 20453838 17529967 23535729 29059683 27117709 ) Breast cancer (estrogen-receptor negative) ( 27117709 ) Celiac disease ( 23936387 ) Central corneal thickness ( 32528159 ) Diastolic blood pressure ( 30487518 27618452 27841878 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hypertension ( 30487518 ) Inflammatory bowel disease ( 28067908 23128233 ) Lymphocyte count ( 32888494 ) Mammographic density (dense area) ( 25342443 ) Mean arterial pressure ( 29403010 30487518 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (antihypertensives) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Methadone dose in opioid dependence ( 28115739 ) Milk allergy ( 25710614 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Potassium levels ( 29403010 ) Pulse pressure ( 30578418 27841878 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure ( 27618452 29403010 30487518 30578418 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Ulcerative colitis ( 28067908 21297633 )
Interacting Genes		72 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CEBPA CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FNDC3B FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC00941 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WEE2-AS1 WIPF1	11 interacting genes: ACTG1 BMPR2 CFTR GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		71	4046
HPRD ID		00017	01083
Ensembl ID		ENSG00000184009	ENSG00000130592
Uniprot IDs		P63261	A8K7L8 P33241
PDB IDs		5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2 7NVM 8DNF	3BH8 4NO0 4NO2
GO Terms Enriched among Interactors		Actin Binding Actin Filament Organization Actin Filament-based Process Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Actin Filament Binding Cytoskeleton Actin Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Actin Filament Severing Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Lamellipodium Cell Projection Organization Cytoplasm Modification Of Postsynaptic Structure Positive Regulation Of Cellular Component Organization Modification Of Synaptic Structure Regulation Of Protein-containing Complex Disassembly Glutamatergic Synapse Positive Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cytoskeleton Organization Actin Filament Fragmentation Protein Depolymerization Organelle Organization Plasma Membrane Bounded Cell Projection Organization Presynapse Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis	None