ACTG1 and GIT2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ACTG1	GIT2
Name		actin gamma 1	GIT ArfGAP 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Myofibril Axon Filamentous Actin NuA4 Histone Acetyltransferase Complex Apical Junction Complex Calyx Of Held Apical Part Of Cell Synapse Phagocytic Vesicle Extracellular Exosome Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Basal Body Patch	Nucleoplasm Focal Adhesion Synapse Presynapse
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Hydrolase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Angiogenesis Morphogenesis Of A Polarized Epithelium Axonogenesis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Sarcomere Organization Cell Motility Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Platelet Aggregation Cellular Response To Type II Interferon Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Protein Localization To Bicellular Tight Junction	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs		Copper Artenimol	None
GWAS		Alanine aminotransferase levels ( 33339817 33547301 ) Gamma glutamyl transferase levels ( 33339817 ) Hand grip strength ( 29313844 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Refractive error ( 32231278 )	Bipolar disorder ( 31043756 ) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980 ) Metabolic syndrome ( 20694148 ) Metabolite levels ( 23823483 ) Metabolite levels (MHPG) ( 23319000 )
Interacting Genes		72 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CEBPA CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FNDC3B FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC00941 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WEE2-AS1 WIPF1	47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		71	9815
HPRD ID		00017	09779
Ensembl ID		ENSG00000184009	ENSG00000139436
Uniprot IDs		P63261	F8VXI9 F8W822 Q14161 Q6FI58
PDB IDs		5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2 7NVM 8DNF	Not available
GO Terms Enriched among Interactors		Actin Binding Actin Filament Organization Actin Filament-based Process Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Actin Filament Binding Cytoskeleton Actin Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Actin Filament Severing Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Lamellipodium Cell Projection Organization Cytoplasm Modification Of Postsynaptic Structure Positive Regulation Of Cellular Component Organization Modification Of Synaptic Structure Regulation Of Protein-containing Complex Disassembly Glutamatergic Synapse Positive Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cytoskeleton Organization Actin Filament Fragmentation Protein Depolymerization Organelle Organization Plasma Membrane Bounded Cell Projection Organization Presynapse Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis	Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation