ACTG1 and FPR1

Number of citations of the paper that reports this interaction (PMID 8228254)
11

Data Source:
HPRD (in vitro)

		ACTG1	FPR1
Gene Name		actin gamma 1	formyl peptide receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle	Endosome Plasma Membrane Integral Component Of Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Receptor Activity N-formyl Peptide Receptor Activity Protein Binding RAGE Receptor Binding
	Biological Process	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction
Pathways		Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formyl peptide receptors bind formyl peptides and many other ligands
Drugs			Nedocromil
Diseases
GWAS
Protein-Protein Interactions		60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1	5 interactors: ACTG1 ADRBK1 ANXA1 GNAI2 SAA1
Entrez ID		71	2357
HPRD ID		00017	00646
Ensembl ID		ENSG00000184009
Uniprot IDs		P63261	P21462
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction	G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell Activation Platelet Activation Defense Response Blood Coagulation Hemostasis Response To Stress Regulation Of Phospholipase Activity Regulation Of Body Fluid Levels Wound Healing Regulation Of Secretion Endocytosis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Neutrophil Clearance Response To Wounding Positive Regulation Of Transport Regulation Of Cytokine Secretion Immune System Process Innate Immune Response DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Negative Regulation Of Phospholipase A2 Activity Regulation Of Cellular Localization Negative Regulation Of Interleukin-8 Secretion Prolactin Secretion Positive Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Phospholipase Activity Cell Surface Receptor Signaling Pathway Immune Response Negative Regulation Of Striated Muscle Contraction Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Stimulus Homeostatic Process Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Tachykinin Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Myeloid Cell Apoptotic Process Receptor-mediated Endocytosis Regulation Of Phospholipase A2 Activity Positive Regulation Of Catecholamine Secretion Movement Of Cell Or Subcellular Component DNA Strand Renaturation Arachidonic Acid Secretion Regulation Of Protein Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Adenosine Receptor Signaling Pathway Negative Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Secretion Inflammatory Response
Tagcloud ?		alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	amplified c5a c5ar chromosomes complement contained digestion electrophoresis filters formylpeptides fpr2 fprl2 fragment homologue hybridized il8ra il8rb kb kilobase library lie linkage mapped nylon probes pulsed restriction separated translated
Tagcloud (Difference) ?		alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	amplified c5a c5ar chromosomes complement contained digestion electrophoresis filters formylpeptides fpr2 fprl2 fragment homologue hybridized il8ra il8rb kb kilobase library lie linkage mapped nylon probes pulsed restriction separated translated
Tagcloud (Intersection) ?