SETDB1 and TK1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		SETDB1	TK1
Gene Name		SET domain, bifurcated 1	thymidine kinase 1, soluble
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs			Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS		Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24	159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		9869	7083
HPRD ID		06828	01771
Ensembl ID		ENSG00000143379	ENSG00000167900
Uniprot IDs		Q15047	P04183
PDB IDs		3DLM	1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle	Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus
Tagcloud ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Difference) ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Intersection) ?