SETDB1 and PLEKHA4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SETDB1	PLEKHA4
Gene Name		SET domain, bifurcated 1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle	Cellular_component Cytoplasm Membrane
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity	1-phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development	Biological_process
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24	6 interactors: CCNG1 EEF1G KAT5 LRIF1 PRKAA1 SETDB1
Entrez ID		9869	57664
HPRD ID		06828	09683
Ensembl ID		ENSG00000143379	ENSG00000105559
Uniprot IDs		Q15047	Q9H4M7
PDB IDs		3DLM	1UPQ 1UPR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle	Histone Modification Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Chromatin Modification Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Organization Response To Ionizing Radiation Negative Regulation Of Glucose Import In Response To Insulin Stimulus Response To Camptothecin Transcription, DNA-templated Peptidyl-amino Acid Modification RNA Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chromosome Organization Peptidyl-lysine Modification Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Histone H3-K9 Trimethylation Cellular Response To Ethanol Negative Regulation Of Glucose Import Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Fatty Acid Homeostasis Organelle Organization RNA Metabolic Process Negative Regulation Of Glucose Transport Mitotic G2 DNA Damage Checkpoint Cellular Response To Stress Cellular Response To Estradiol Stimulus Negative Regulation Of Interleukin-2 Production Negative Regulation Of Cell Cycle Response To Radiation Histone H3-K9 Methylation Regulation Of Glucose Import In Response To Insulin Stimulus Inner Cell Mass Cell Proliferation Regulation Of Cholesterol Biosynthetic Process Histone-serine Phosphorylation Growth Negative Regulation Of Lipid Catabolic Process Cellular Response To Glucose Starvation Positive Regulation Of Protein Acetylation Peptidyl-lysine Trimethylation Response To Caffeine
Tagcloud ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Difference) ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Intersection) ?