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SETDB1 and SMN1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
SETDB1
SMN1
Description
SET domain bifurcated histone lysine methyltransferase 1
survival of motor neuron 1, telomeric
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Perikaryon
Gemini Of Cajal Bodies
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Histone Methyltransferase Activity
Metal Ion Binding
Histone H3K9 Methyltransferase Activity
Histone H3 Methyltransferase Activity
Histone H3K9me2 Methyltransferase Activity
Histone H3K9 Monomethyltransferase Activity
Histone H3K9 Trimethyltransferase Activity
Promoter-specific Chromatin Binding
RNA Binding
Protein Binding
Identical Protein Binding
Biological Process
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Negative Regulation Of Gene Expression
Methylation
Heterochromatin Organization
Transposable Element Silencing By Heterochromatin Formation
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
DNA-templated Transcription Termination
MRNA Processing
Nervous System Development
RNA Splicing
Pathways
PKMTs methylate histone lysines
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
snRNP Assembly
SARS-CoV-2 modulates host translation machinery
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Body mass index (
26426971
)
Caffeine consumption from coffee or tea (
33287642
)
Caffeine consumption from tea (
33287642
)
Chronic kidney disease (
20383146
)
Coffee consumption (
31046077
)
Cutaneous squamous cell carcinoma (
32041948
)
Hip circumference adjusted for BMI (
34021172
)
Melanoma (
21983785
)
Neurological blood protein biomarker levels (
31320639
)
Nevus count or cutaneous melanoma (
30429480
)
Interacting Genes
110 interacting genes:
AIFM1
AKT1
ANXA7
APC
APLP1
ASAH1
ATF7IP
ATF7IP2
BAG6
BARD1
BHLHE40
BID
BRIX1
BTBD2
BTG3
CBX8
CCDC106
CDK4
CDKN1A
CFAP68
CLSTN1
CREBBP
CRELD1
DAP
DLEU1
DNMT3A
ECSIT
ERG
ERH
FAM118B
FLYWCH1
GIPC2
GPS2
GRB7
GSTO1
H3-4
H3C1
H3C15
H4C16
HDAC1
HDAC2
HMOX2
HSPB3
JARID2
KDM1A
LRIF1
LUC7L2
MAD2L1BP
MAP4K5
MBD1
MDM2
MOB4
MRPL44
MZT2B
NIPSNAP3A
OLFML3
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PGAM5
PHF10
PIAS4
PLEKHA4
POLA2
PPA1
PPP1R8
PRKRA
PSMD11
PSME1
PTPRS
QTRT1
RIF1
RNF10
S100A10
SAT1
SERPINB9
SIN3A
SIN3B
SKIL
SLC38A3
SMN1
SNIP1
SUFU
SULT1E1
SUMO2
TARDBP
TCERG1
THAP8
TK1
TOB1
TOLLIP
TPI1
TRBV2
TRDMT1
TRIB3
TRIM16
TRIM28
TRIP6
TSC22D1
TTR
TXNDC9
UBE2I
ULK2
USP11
VHL
VIM
ZFP64
ZNF24
166 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
FXR1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NEURL2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
Entrez ID
9869
6606
HPRD ID
06828
02646
Ensembl ID
ENSG00000143379
ENSG00000172062
Uniprot IDs
A0A8I5KT93
Q15047
X6R732
B4DP61
E7EQZ4
Q16637
PDB IDs
3DLM
4X3S
5KCH
5KCO
5KE2
5KE3
5KH6
5QT1
5QT2
6AU2
6AU3
6BHD
6BHE
6BHG
6BHH
6BHI
6BPI
7C9N
7CAJ
7CD9
7CJT
8G5E
8IYA
8UWP
9CUW
9CUX
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
7W2P
7W30
Enriched GO Terms of Interacting Partners
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Transcription Corepressor Activity
Nucleus
Nucleoplasm
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Heterochromatin Formation
Negative Regulation Of Gene Expression, Epigenetic
SUMO Transferase Activity
Regulation Of RNA Metabolic Process
Chromatin Remodeling
Epigenetic Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Transcription Coregulator Activity
Constitutive Heterochromatin Formation
Cytoplasm
MRF Binding
Chromatin Binding
Transcription Regulator Complex
DNA Methylation-dependent Constitutive Heterochromatin Formation
Ubiquitin Protein Ligase Binding
Sin3-type Complex
Regulation Of Mitotic Cell Cycle Phase Transition
Heterochromatin
Protein Sumoylation
Nuclear Matrix
Nuclear Body
RNA Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Proteolysis
Krueppel-associated Box Domain Binding
Enzyme Binding
Spliceosomal SnRNP Assembly
RNA Binding
MRNA Metabolic Process
RNA Splicing
MRNA Processing
RNA Splicing, Via Transesterification Reactions
SMN-Sm Protein Complex
RNA Processing
Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Protein-RNA Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Metabolic Process
U2-type Precatalytic Spliceosome
Spliceosomal Complex
Lsm2-8 Complex
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
U6 SnRNP
Lsm1-7-Pat1 Complex
Nucleoplasm
Precatalytic Spliceosome
SMN Complex
U4 SnRNP
Catalytic Step 2 Spliceosome
Telomerase Holoenzyme Complex
U7 SnRNP
Macromolecule Metabolic Process
7-methylguanosine Cap Hypermethylation
Small Nuclear Ribonucleoprotein Complex
Nucleus
Gemini Of Cajal Bodies
Methylosome
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Spliceosomal Tri-snRNP Complex
Cytosol
U2 SnRNP
Spliceosomal Complex Assembly
Protein-containing Complex Assembly
U1 SnRNP
U7 SnRNA Binding
U5 SnRNP
Cytoplasm
Cajal Body
Histone Pre-mRNA DCP Binding
U2-type Prespliceosome Assembly
Protein-containing Complex Organization
U6 SnRNA Binding
Promoter-specific Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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