SETDB1 and SLC38A3

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		SETDB1	SLC38A3
Name		SET domain bifurcated histone lysine methyltransferase 1	solute carrier family 38 member 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding	L-histidine Transmembrane Transporter Activity Neutral L-amino Acid:sodium Symporter Activity Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Symporter Activity Antiporter Activity L-glutamine, Sodium:proton Antiporter Activity L-asparagine, Sodium:proton Antiporter Activity L-histidine, Sodium:proton Antiporter Activity
	Biological Process	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation	Amino Acid Transmembrane Transport Monoatomic Ion Transport Sodium Ion Transport Amino Acid Transport Asparagine Transport Glutamine Transport Female Pregnancy Glutamine Secretion L-alanine Transport Histidine Transport Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Potassium Ion Starvation Intracellular Amino Acid Homeostasis Transport Across Blood-brain Barrier L-histidine Transport L-glutamine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane L-asparagine Import Across Plasma Membrane Positive Regulation Of Glutamine Transport
Pathways		PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Amino acid transport across the plasma membrane
Drugs		None	Histidine Asparagine
GWAS		Body mass index ( 26426971 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Chronic kidney disease ( 20383146 ) Coffee consumption ( 31046077 ) Cutaneous squamous cell carcinoma ( 32041948 ) Hip circumference adjusted for BMI ( 34021172 ) Melanoma ( 21983785 ) Neurological blood protein biomarker levels ( 31320639 ) Nevus count or cutaneous melanoma ( 30429480 )	Body mass index ( 26426971 ) Conotruncal heart defects (maternal effects) ( 28468790 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Sleep duration (short sleep) ( 30846698 ) Smoking status (ever vs never smokers) ( 30643258 )
Interacting Genes		110 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24	3 interacting genes: COL6A2 HMGN1 SETDB1
Entrez ID		9869	10991
HPRD ID		06828	11980
Ensembl ID		ENSG00000143379	ENSG00000188338
Uniprot IDs		A0A8I5KT93 Q15047 X6R732	Q99624
PDB IDs		3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX	Not available
GO Terms Enriched among Interactors		Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding	Collagen Type VI Trimer Response To Radiation Response To Light Stimulus Response To UV Pyrimidine Dimer Repair Regulation Of Development, Heterochronic Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Female Germ Cell Nucleus Post-embryonic Camera-type Eye Morphogenesis Response To UV-C Post-embryonic Eye Morphogenesis T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Heterochromatin Organization Histone H3K9 Trimethyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Methyltransferase Activity Chromatin Binding Response To UV-B Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Myoblast Fusion Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Histone H3 Methyltransferase Activity Transposable Element Silencing By Heterochromatin Formation