SETDB1 and PPP1R8

Number of citations of the paper that reports this interaction (PubMedID 29581310)
62

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		SETDB1	PPP1R8
Description		SET domain bifurcated histone lysine methyltransferase 1	protein phosphatase 1 regulatory subunit 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding	DNA Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity Hydrolase Activity Protein Phosphatase Regulator Activity Molecular Function Inhibitor Activity
	Biological Process	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing
Pathways		PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		110 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24	28 interacting genes: APP APPBP2 CDC5L CNKSR1 CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77
Entrez ID		9869	5511
HPRD ID		06828	04028
Ensembl ID		ENSG00000143379	ENSG00000117751
Uniprot IDs		A0A8I5KT93 Q15047 X6R732	Q12972 Q6ICT4
PDB IDs		3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX	3V4Y
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding	Macromolecule Metabolic Process Nucleoplasm Postsynapse Cellular Response To Catecholamine Stimulus Response To Catecholamine Protein Modification Process Protein Kinase CK2 Complex Intracellular Signal Transduction Protein Metabolic Process Spliceosomal Complex Cellular Response To Stress Regulation Of Proteolysis Enzyme Binding MRNA Metabolic Process Rhythmic Process Cellular Response To Dopamine PTW/PP1 Phosphatase Complex Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Signaling Receptor Activator Activity Nucleobase-containing Compound Metabolic Process MRNA Processing Response To Dopamine Cellular Response To Heat Perikaryon Cellular Response To Manganese Ion Chromatin Binding Protein Kinase Activity DNA Repair Positive Regulation Of Gliogenesis Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Circadian Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Programmed Cell Death Nucleus Response To Manganese Ion Prp19 Complex Protein Serine Kinase Activity Golgi-associated Vesicle Chromatin Organization Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process RNA Splicing MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy ESC/E(Z) Complex Negative Regulation Of Gene Expression
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