SETDB1 and APC

Number of citations: 36 (PubMedID 20936779)
Data Source: BioGRID (two hybrid)

		SETDB1	APC
Name		SET domain bifurcated histone lysine methyltransferase 1	APC regulator of Wnt signaling pathway
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Beta-catenin Destruction Complex Leading Edge Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Plasma Membrane Bounded Cell Projection Wnt Signalosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding
	Biological Process	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation	Mitotic Cytokinesis Cell Fate Specification Heart Valve Development Endocardial Cushion Morphogenesis DNA Damage Response Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Assembly Checkpoint Signaling Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule-based Movement Protein-containing Complex Assembly Bicellular Tight Junction Assembly Regulation Of Primary Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases
Diseases		None	Cancer of the anal canal Familial adenomatous polyposis Gastric cancer Esophageal cancer Gallbladder cancer
GWAS		Body mass index ( 26426971 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Chronic kidney disease ( 20383146 ) Coffee consumption ( 31046077 ) Cutaneous squamous cell carcinoma ( 32041948 ) Hip circumference adjusted for BMI ( 34021172 ) Melanoma ( 21983785 ) Neurological blood protein biomarker levels ( 31320639 ) Nevus count or cutaneous melanoma ( 30429480 )	Age at first sexual intercourse ( 34211149 ) Angiotensin-converting enzyme inhibitor intolerance ( 28030426 ) Appendicular lean mass ( 33097823 ) Body mass index ( 29273807 ) Colorectal cancer or advanced adenoma ( 30510241 ) Daytime nap ( 33568662 ) Heel bone mineral density ( 30598549 ) Reaction time ( 29844566 ) Total body bone mineral density ( 29304378 )
Interacting Genes		110 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24	135 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 ATOSA AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG1 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PKNOX1 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 ZNF106 ZNF510
Entrez ID		9869	324
HPRD ID		06828	01439
Ensembl ID		ENSG00000143379	ENSG00000134982
Uniprot IDs		A0A8I5KT93 Q15047 X6R732	P25054 R4GMU6
PDB IDs		3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX	1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H 7F6M 7F7O 7XTY 8GSJ 8X2Q
GO Terms Enriched among Interactors		Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding	Organelle Organization Structural Constituent Of Nuclear Pore Cytoskeleton Organization Supramolecular Fiber Organization Cytosol MRNA Transport Nuclear Export Nuclear Pore Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Beta-catenin Destruction Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Nuclear Membrane RNA Export From Nucleus Cellular Localization Cytoskeleton Intracellular Protein Localization Regulation Of Nucleocytoplasmic Transport Intracellular Transport Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Nuclear Envelope Establishment Of Localization In Cell Cadherin Binding Regulation Of Protein Localization Actin Filament Binding Glutamatergic Synapse Regulation Of Cellular Localization Protein Export From Nucleus Hemidesmosome Intracellular Protein Transport Actin Binding Nucleus Protein Transport Cellular Component Assembly Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Cytoplasm Regulation Of Cytoskeleton Organization Canonical Wnt Signaling Pathway Regulation Of Intracellular Transport Structural Molecule Activity Intermediate Filament Organization Nuclear Pore Nuclear Basket Regulation Of Intracellular Protein Transport Nuclear Pore Organization Microtubule Regulation Of Centromeric Sister Chromatid Cohesion