SETDB1 and ECSIT

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SETDB1	ECSIT
Gene Name		SET domain, bifurcated 1	ECSIT signalling integrator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		9869	51295
HPRD ID		06828	12225
Ensembl ID		ENSG00000143379	ENSG00000130159
Uniprot IDs		Q15047	K7EMM0 Q9BQ95
PDB IDs		3DLM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?