MRFAP1 and PCNT

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		MRFAP1	PCNT
Name		Morf4 family associated protein 1	pericentrin
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	None	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways		None	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Diseases		None	Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		No GWAS studies recorded	Heel bone mineral density ( 30598549 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) S100 calcium-binding protein levels ( 33227023 ) Treatment resistant depression ( 30468137 )
Interacting Genes		40 interacting genes: ABI1 ABI2 ABI3 BRK1 C3orf62 C8orf33 CAVIN3 CCDC146 DCDC2 DNAJB5 DPY30 FCHSD2 GOLGA8F GOLGA8G HTT KIFC3 MAP1LC3B MORF4L1 MORF4L2 MTIF3 PAM16 PCBD2 PCNT PRAP1 PRKAA2 SDCBP SH2D4A SMU1 SUV39H2 TEX11 TK1 TPM2 TRIM47 TXN TXN2 UBTD1 UQCC2 WASHC1 ZDHHC17 ZNF655	55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1
Entrez ID		93621	5116
HPRD ID		17589	05804
Ensembl ID		ENSG00000179010	ENSG00000160299
Uniprot IDs		B3KQA0 Q9Y605	O95613
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Regulation Of Actin Nucleation Positive Regulation Of Actin Nucleation Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Organelle Organization Regulation Of Lamellipodium Organization Regulation Of Organelle Organization Regulation Of Organelle Assembly Cytoskeleton Actin Filament Organization Neuron Migration Cell Projection Morphogenesis Centriole Filopodium Tip Signaling Adaptor Activity Autophagosome Lamellipodium	Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity