PCNT and DNM3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	DNM3
Description		pericentrin	dynamin 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Postsynaptic Density Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Endocytosis Synapse Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Filopodium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 28135244 27841878) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 28869591 30598549) Height ( 28552196 20881960 23563607 25282103 25429064 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29083408) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Mean platelet volume ( 27863252 32888494 24026423 22139419 19820697) Ovarian cancer ( 30557369) Platelet count ( 33545615 29403010 32888494 22139419 27863252) Platelet distribution width ( 32888494 27863252) QT interval (sulfonylurea treatment interaction) ( 27958378) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Uterine fibroids ( 31249589) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	6 interacting genes: DYNLL1 DYRK1A HOMER1 HSPA13 PCNT SNCA
Entrez ID		5116	26052
HPRD ID		05804	13241
Ensembl ID		ENSG00000160299	ENSG00000197959
Uniprot IDs		O95613	H0YBC6 Q9UQ16
PDB IDs			3L43 5A3F
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	Negative Regulation Of Microtubule Polymerization Behavioral Response To Cocaine Regulation Of Microtubule Polymerization Axon Microtubule Regulation Of Amide Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Histone H3T45 Kinase Activity Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Enzyme Inhibitor Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Tetramerization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Calcium Ion Transport Cytoskeleton Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Centrosome Negative Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Intracellular Transport Regulation Of Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity G Protein-coupled Glutamate Receptor Binding Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Heterochromatin Formation Molecular Adaptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Monoatomic Ion Transport Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly
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