MRFAP1 and TPM2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MRFAP1	TPM2
Name		Morf4 family associated protein 1	tropomyosin 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton
	Molecular Function	Protein Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	None	Muscle Contraction Actin Filament Organization Regulation Of ATP-dependent Activity
Pathways		None	Striated Muscle Contraction Smooth Muscle Contraction
Diseases		None	Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		No GWAS studies recorded	Immature fraction of reticulocytes ( 32888494 ) Platelet count ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		40 interacting genes: ABI1 ABI2 ABI3 BRK1 C3orf62 C8orf33 CAVIN3 CCDC146 DCDC2 DNAJB5 DPY30 FCHSD2 GOLGA8F GOLGA8G HTT KIFC3 MAP1LC3B MORF4L1 MORF4L2 MTIF3 PAM16 PCBD2 PCNT PRAP1 PRKAA2 SDCBP SH2D4A SMU1 SUV39H2 TEX11 TK1 TPM2 TRIM47 TXN TXN2 UBTD1 UQCC2 WASHC1 ZDHHC17 ZNF655	22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785
Entrez ID		93621	7169
HPRD ID		17589	11768
Ensembl ID		ENSG00000179010	ENSG00000198467
Uniprot IDs		B3KQA0 Q9Y605	A7XZE4 P07951 Q5TCU3 V9HW25
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Regulation Of Actin Nucleation Positive Regulation Of Actin Nucleation Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Organelle Organization Regulation Of Lamellipodium Organization Regulation Of Organelle Organization Regulation Of Organelle Assembly Cytoskeleton Actin Filament Organization Neuron Migration Cell Projection Morphogenesis Centriole Filopodium Tip Signaling Adaptor Activity Autophagosome Lamellipodium	Actin Filament Actin Cytoskeleton Sarcomere Negative Regulation Of Striated Muscle Contraction Stress Fiber Adherens Junction Assembly Identical Protein Binding Structural Constituent Of Cytoskeleton Actin Filament Organization Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Transition Metal Ion Binding Negative Regulation Of Blood Circulation