PCNT and DST

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	DST
Description		pericentrin	dystonin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Stress Fiber Basement Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Z Disc Hemidesmosome Axon Cell Leading Edge Cytoplasmic Vesicle H Zone Microtubule Plus-end Cell Projection Intermediate Filament Cytoskeleton Anchoring Junction Cell Periphery Polymeric Cytoskeletal Fiber Axon Cytoplasm
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Actin Binding Integrin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Retrograde Axonal Transport Response To Wounding Maintenance Of Cell Polarity Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization Cell Motility
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Type I hemidesmosome assembly RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	Alzheimer disease and age of onset ( 26830138) Appendicular lean mass ( 33097823) Attention function in attention deficit hyperactive disorder ( 26174813) Cerebrospinal fluid clusterin levels ( 26545630) Daytime sleep phenotypes ( 27126917) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494) Small cell lung carcinoma ( 28604730)
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	50 interacting genes: ABI1 ANKRD1 APC C1QTNF9 CALM1 CDC5L CELSR3 CEP63 CLIP4 COL17A1 DCTN1 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EIF4ENIF1 ERBB2 ERBIN EXOC1 FTCD HUNK ITGB4 ITSN1 ITSN2 KIAA1549 KRT14 KRT5 LINC01554 MAPK6 MORC3 MTNR1B MYBPC2 NFYC NRIP1 PAK2 PCNT PRKAB2 PRKD2 PTGER4 RBM11 RSPH1 SH3BP5 SMAD9 SNAPIN TNIK TRAF3IP1 TTC3 TULP3 USP7
Entrez ID		5116	667
HPRD ID		05804	00222
Ensembl ID		ENSG00000160299	ENSG00000151914
Uniprot IDs		O95613	A0A7P0T890 B4DGY0 B4DSS9 E9PHM6 F6QMI7 F8W9J4 Q03001 Q6P0N6
PDB IDs			3GJO 7OLG
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	Signal Transduction Hemidesmosome Cytoskeleton Organization Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Centrosome Developmental Process Cytosol Hemidesmosome Assembly Cytoplasm Vesicle-mediated Transport In Synapse Organelle Organization Molecular Adaptor Activity Anatomical Structure Morphogenesis Cytoskeleton Regulation Of Neuron Projection Development Ciliary Base Presynaptic Endocytosis Cellular Component Assembly Cell Junction Organization Dendrite Morphogenesis Cell Surface Receptor Signaling Pathway Protein Binding Microtubule-based Process Protein Phosphorylation Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Titin Binding Nucleoplasm Cell Junction Assembly Regulation Of Cell Projection Organization Cell Projection Assembly Cell Leading Edge Cilium Assembly Axonal Transport Organelle Assembly Neuron Cellular Homeostasis Dendritic Spine Development Neuron Projection Morphogenesis Phosphorylation Basal Plasma Membrane Protein Tyrosine Kinase Activator Activity Embryonic Camera-type Eye Development Negative Regulation Of Interferon-beta Production Anterograde Synaptic Vesicle Transport BLOC-1 Complex Positive Regulation Of Cell Growth
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