PCNT and CCP110

Number of citations: 39 (PubMedID 16760425)
Data Source: HPRD (in vivo)

		PCNT	CCP110
Name		pericentrin	centriolar coiled-coil protein 110
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Protein-containing Complex Cell Projection
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Centriole Replication Cell Projection Organization Ciliary Basal Body Organization Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Centrosome Duplication Negative Regulation Of Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2 RHOV GTPase cycle
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome	None
GWAS		Heel bone mineral density ( 30598549 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) S100 calcium-binding protein levels ( 33227023 ) Treatment resistant depression ( 30468137 )	No GWAS studies recorded
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	14 interacting genes: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 DCAF1 PCNT PNMA1 TFIP11 USP33 USP7
Entrez ID		5116	9738
HPRD ID		05804	10848
Ensembl ID		ENSG00000160299	ENSG00000103540
Uniprot IDs		O95613	O43303
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	Centrosome Cytoskeleton G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of High Voltage-gated Calcium Channel Activity Microtubule Organizing Center Organization Centriole Replication Cytoplasm Regulation Of Cardiac Muscle Cell Action Potential Cyclin-dependent Protein Kinase Activity Centriole Assembly VCB Complex Mitotic Cell Cycle Phase Transition Spindle Microtubule Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Cell Cycle Phase Transition Histone Kinase Activity Centriole Protection From Non-homologous End Joining At Telomere Heterotrimeric G-protein Binding Regulation Of Action Potential Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Cycle Process DNA Metabolic Process Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Voltage-gated Potassium Channel Complex Post-translational Protein Modification Titin Binding Regulation Of Cytokinesis Telomere Maintenance In Response To DNA Damage Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Organelle Organization Microtubule Organizing Center Protein Deubiquitination Regulation Of Cell Communication By Electrical Coupling Regulation Of Heart Rate Protein Phosphatase Activator Activity Calyx Of Held Centrosome Duplication Protein Modification By Small Protein Removal G-protein Beta/gamma-subunit Complex Binding Regulation Of Cell Cycle Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion