PCNT and MYT1L

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	MYT1L
Description		pericentrin	myelin transcription factor 1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Chromatin Nucleus Chromosome
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Zinc Ion Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Cobalt Ion Binding Metal Ion Sequestering Activity
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Caudate nucleus volume ( 31530798) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Glucose homeostasis traits ( 25524916) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (functional units) ( 27694959) Impulsivity ( 30718321) Impulsivity (motor) ( 30718321) Impulsivity (non-planning) ( 30718321) Inflammatory skin disease ( 25574825) Mitochondrial DNA copy number (white blood cells) ( 30704525) Moderate-to-late spontaneous preterm birth ( 31194736) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Systemic sclerosis ( 30247649) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Type 2 diabetes (age of onset) ( 28060188) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	6 interacting genes: AURKA CDC5L DISC1 DYRK1A PCNT TGFBR1
Entrez ID		5116	23040
HPRD ID		05804	14797
Ensembl ID		ENSG00000160299	ENSG00000186487
Uniprot IDs		O95613	A0A2R8YF72 A0A3B3IRM3 A0A3B3IRX5 A0A3B3IS14 A0A3B3IS61 A0A3B3ISW5 Q9UL68
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	Microtubule Microtubule Organizing Center Protein Serine/threonine/tyrosine Kinase Activity Centrosome Protein Localization To Centrosome Plasma Membrane Bounded Cell Projection Organization Cilium Organization Peptidyl-serine Phosphorylation Protein Localization To Cytoskeleton Protein Phosphorylation Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Phosphorylation Cell Projection Organization Protein Serine/threonine Kinase Activity Histone H3T45 Kinase Activity Microtubule Cytoskeleton Organization Mitotic Spindle Organization Protein Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Autophosphorylation Nervous System Development Regulation Of Signal Transduction By P53 Class Mediator Cytoskeleton Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Oocyte Maturation Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Centriole Spindle Organization Organelle Assembly Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process WD40-repeat Domain Binding Negative Regulation Of Heterochromatin Formation
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