PCNT and ST18

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		PCNT	ST18
Name		pericentrin	ST18 C2H2C-type zinc finger transcription factor
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Chromatin Nucleus Protein-DNA Complex
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Interleukin-6-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	None
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome	None
GWAS		Heel bone mineral density ( 30598549 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) S100 calcium-binding protein levels ( 33227023 ) Treatment resistant depression ( 30468137 )	Age at first sexual intercourse ( 34211149 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Chronotype ( 30696823 ) Frontotemporal dementia (age at onset) ( 29724592 ) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma (primary angle closure) ( 27064256 ) Morning person ( 30696823 ) Motion sickness ( 25628336 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 ) Psychotic experience (distressing) ( 31553412 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Type 2 diabetes ( 31049640 )
Novel Interactors		10 novel interactors: CDK12 COL6A1 HPRT1 NDUFV3 PDE9A PFKL PKNOX1 RAC3 S100B SH3BGR	None recorded
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	2 interacting genes: HSPA13 PCNT
Entrez ID		5116	9705
HPRD ID		05804	18110
Ensembl ID		ENSG00000160299	ENSG00000147488
Uniprot IDs		O95613	O60284
PDB IDs		Not available	2CS8
GO Terms Enriched among Interactors		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	None