PCNT and YY1AP1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	YY1AP1
Description		pericentrin	YY1 associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Ino80 Complex
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Cell Population Proliferation Cell Differentiation Regulation Of Cell Cycle
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	12 interacting genes: ATXN1 ATXN1L EWSR1 FXR1 MAD2L2 MAPK14 MAPK8IP2 MDM2 PCNT PRKAB2 VHL ZFAT
Entrez ID		5116	55249
HPRD ID		05804	08485
Ensembl ID		ENSG00000160299	ENSG00000163374
Uniprot IDs		O95613	B4DQQ0 I6L9C2 Q9H869
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	POZ Domain Binding Social Behavior Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process JUN Kinase Binding Positive Regulation Of Intracellular Protein Transport Regulation Of RNA Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Developmental Process Negative Regulation Of Catabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Amyloid Fibril Formation Learning Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleolus Ribonucleoprotein Complex Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Cytoplasm Lung Alveolus Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Protein Transport Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Formaldehyde Cellular Response To Vitamin B1 DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Intracellular Transport Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Metabolic Process Learning Or Memory Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Muscle Cell Differentiation
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