PCNT and PARVB

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	PARVB
Description		pericentrin	parvin beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Actin Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Cell Adhesion Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Lewy body disease ( 25188341) Monocyte count ( 32888494) Nonalcoholic fatty liver disease ( 22719876) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systemic sclerosis (anti-centromere-positive) ( 29293537)
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	3 interacting genes: ARHGEF6 ILK PCNT
Entrez ID		5116	29780
HPRD ID		05804	16284
Ensembl ID		ENSG00000160299	ENSG00000188677
Uniprot IDs		O95613	A0A087WZB5 Q9HBI1
PDB IDs			4EDL 4EDM 4EDN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	Spindle Organization Mitotic Spindle Organization Cell Projection Organization Microtubule Cytoskeleton Organization Involved In Mitosis Lamellipodium Protein Localization To Cell Cortex Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Plasma Membrane Raft Assembly Schwann Cell Development Microtubule Cytoskeleton Organization Membrane Raft Assembly Plasma Membrane Raft Organization Caveola Assembly Cellular Component Assembly Fibroblast Migration Myelination In Peripheral Nervous System Centrosome Membrane Raft Organization Negative Regulation Of Neural Precursor Cell Proliferation Microtubule Nucleation Branching Involved In Ureteric Bud Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Assembly Tumor Necrosis Factor-mediated Signaling Pathway Nerve Development Intracellular Signaling Cassette Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Platelet Aggregation Outflow Tract Morphogenesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Sarcomere Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Substrate Adhesion-dependent Cell Spreading Microtubule-based Process Positive Regulation Of BMP Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Lamellipodium Assembly Lamellipodium Organization JNK Cascade Glial Cell Development Homotypic Cell-cell Adhesion
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